Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance.

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Title: Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance.
Authors: Tao R; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Stöhr O; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Tok O; Dept. Molecular Metabolism, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, USA., Andres-Hernando A; Division of Endocrinology, Metabolism & Diabetes, Univ. of Colorado Anschutz School of Medicine, 12801 East 17th Avenue, Aurora, CO, USA., Qiu W; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., He B; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Wang C; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Grøntved L; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Burant C; Section of Metabolism, Endocrinology, and Diabetes, Department of Internal medicine, University of Michigan, Ann Arbor, MI, USA., Hui S; Dept. Molecular Metabolism, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, USA., Lanaspa MA; Division of Endocrinology, Metabolism & Diabetes, Univ. of Colorado Anschutz School of Medicine, 12801 East 17th Avenue, Aurora, CO, USA., Stefan N; Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital Tübingen, Tübingen, Germany.; Institute of Diabetes Research and Metabolic Diseases (IDM) of the Helmholtz Center Munich, Tübingen, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Copps KD; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., White MF; Division of Endocrinology Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. morris.white@childrens.harvard.edu.
Source: Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 11595. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2041-1723
DOI:10.1038/s41467-025-66296-5