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Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis.

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Title: Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis.
Authors: Bigotte M; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Groh AMR; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Afanasiev E; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Wong V; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Lancon K; Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, H3A 2B4, Canada., Yaqubi M; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Creeggan F; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Sinott A; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Pei J; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Moore CS; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, A1B 3V6, Canada., Harroud A; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal, QC, H3A 0C7, Canada.; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, H3A OC7, Canada.; Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, 171 76, Sweden., Schneider R; St. Michael's Hospital, Unity Health Toronto, Toronto, ON, M5B 1W8, Canada., Séguéla P; Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, H3A 2B4, Canada., Charabati M; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada., Tea F; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada., Fournier AP; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada., Wang YC; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, H3A OC7, Canada., Ragoussis J; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, H3A OC7, Canada., Prat A; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada., Thebault S; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Zandee S; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada., Stratton JA; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.
Source: Brain : a journal of neurology [Brain] 2025 Nov 24. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE
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  Data: Cerebrospinal fluid-driven ependymal motile cilia defects are implicated in multiple sclerosis.
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  Data: <searchLink fieldCode="AU" term="%22Bigotte+M%22">Bigotte M</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Groh+AMR%22">Groh AMR</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Afanasiev+E%22">Afanasiev E</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Wong+V%22">Wong V</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Lancon+K%22">Lancon K</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Yaqubi+M%22">Yaqubi M</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Creeggan+F%22">Creeggan F</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Sinott+A%22">Sinott A</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Pei+J%22">Pei J</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Moore+CS%22">Moore CS</searchLink>; Division of BioMedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, A1B 3V6, Canada.<br /><searchLink fieldCode="AU" term="%22Harroud+A%22">Harroud A</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.; Department of Human Genetics, McGill University, Montréal, QC, H3A 0C7, Canada.; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, H3A OC7, Canada.; Center for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, 171 76, Sweden.<br /><searchLink fieldCode="AU" term="%22Schneider+R%22">Schneider R</searchLink>; St. Michael's Hospital, Unity Health Toronto, Toronto, ON, M5B 1W8, Canada.<br /><searchLink fieldCode="AU" term="%22Séguéla+P%22">Séguéla P</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, Alan Edwards Centre for Research on Pain, McGill University, Montréal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Charabati+M%22">Charabati M</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Tea+F%22">Tea F</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Fournier+AP%22">Fournier AP</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Wang+YC%22">Wang YC</searchLink>; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, H3A OC7, Canada.<br /><searchLink fieldCode="AU" term="%22Ragoussis+J%22">Ragoussis J</searchLink>; Victor Phillip Dahdaleh Institute of Genomic Medicine, McGill University, Montreal, QC, H3A OC7, Canada.<br /><searchLink fieldCode="AU" term="%22Prat+A%22">Prat A</searchLink>; Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Department of neurosciences, Faculty of Medicine, Université de Montréal, QC, H2X 0A9, Canada.<br /><searchLink fieldCode="AU" term="%22Thebault+S%22">Thebault S</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Zandee+S%22">Zandee S</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.<br /><searchLink fieldCode="AU" term="%22Stratton+JA%22">Stratton JA</searchLink>; Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada.
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        Value: 10.1093/brain/awaf440
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