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Dissecting the Efficacy and Immunogenicity of TLR7 Agonist-Antibody Conjugates through the Lens of Fc Effector Function, Conjugation Strategies, and Linker Cleavability.

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Title: Dissecting the Efficacy and Immunogenicity of TLR7 Agonist-Antibody Conjugates through the Lens of Fc Effector Function, Conjugation Strategies, and Linker Cleavability.
Authors: Fang S; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Benjamin SR; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Wu L; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Rahman MA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Elder KK; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Ojo VT; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Zhang T; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Brooks TA; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States., Tumey LN; School of Pharmacy and Pharmaceutical Sciences, Binghamton University, PO Box 6000, Binghamton, New York 13902-6000, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2025 Dec 11; Vol. 68 (23), pp. 24968-24985. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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        Value: 10.1021/acs.jmedchem.5c01908
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              Text: 2025 Dec 11
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