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Mechanistic insights into dual-active liver and blood-stage antiplasmodials.

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Title: Mechanistic insights into dual-active liver and blood-stage antiplasmodials.
Authors: Rawat M; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Boonyalai N; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom., Smidt C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Luth MR; Department of Pediatrics, University of California San Diego, La Jolla, California, USA., Chen D; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, USA., Plater A; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom., Post J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom., Lin D; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom., McMillan J; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom., Eadsforth T; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom., Moliner-Cubel S; Global Health Medicines R&D, GSK, Severo Ochoa, Tres Cantos, Spain., Billker O; Department of Molecular Biology, Umeå University, Umeå, Sweden.; The Laboratory for Molecular Infection Medicine, Umeå University, Umeå, Sweden., Rayner JC; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Gamo F-J; Global Health Medicines R&D, GSK, Severo Ochoa, Tres Cantos, Spain., Baragaña B; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom., Winzeler EA; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA., Lee MC; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Source: MBio [mBio] 2026 Jan 14; Vol. 17 (1), pp. e0242325. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Rawat+M%22">Rawat M</searchLink>; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Boonyalai+N%22">Boonyalai N</searchLink>; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Smidt+C%22">Smidt C</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Luth+MR%22">Luth MR</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Chen+D%22">Chen D</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.; Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Plater+A%22">Plater A</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Post+J%22">Post J</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lin+D%22">Lin D</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22McMillan+J%22">McMillan J</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Eadsforth+T%22">Eadsforth T</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Moliner-Cubel+S%22">Moliner-Cubel S</searchLink>; Global Health Medicines R&D, GSK, Severo Ochoa, Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Billker+O%22">Billker O</searchLink>; Department of Molecular Biology, Umeå University, Umeå, Sweden.; The Laboratory for Molecular Infection Medicine, Umeå University, Umeå, Sweden.<br /><searchLink fieldCode="AU" term="%22Rayner+JC%22">Rayner JC</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Gamo+F-J%22">Gamo F-J</searchLink>; Global Health Medicines R&D, GSK, Severo Ochoa, Tres Cantos, Spain.<br /><searchLink fieldCode="AU" term="%22Baragaña+B%22">Baragaña B</searchLink>; Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Winzeler+EA%22">Winzeler EA</searchLink>; Department of Pediatrics, University of California San Diego, La Jolla, California, USA.; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Lee+MC%22">Lee MC</searchLink>; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
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