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Microbiota-derived secondary bile acids promote STING activation and antitumor activity.

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Title: Microbiota-derived secondary bile acids promote STING activation and antitumor activity.
Authors: Yang X; Department of Immunology and Microbiology, Scripps Research.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University., Zhang X; Department of Immunology and Microbiology, Scripps Research., Li W; Department of Chemistry, Scripps Research., Gharpure A; Department of Integrative Structural and Computational Biology, Scripps Research., Hansel-Harris A; Department of Integrative Structural and Computational Biology, Scripps Research., Tillack AF; Department of Integrative Structural and Computational Biology, Scripps Research., Wu C; Department of Immunology and Microbiology, Scripps Research., Hsieh YZ; Department of Immunology and Microbiology, Scripps Research., Sulpizio A; Department of Chemistry, Scripps Research., Fam KT; Department of Immunology and Microbiology, Scripps Research., Dikiy S; Department of Immunology and Microbiology, Scripps Research., Zhao X; Department of Immunology and Microbiology, Scripps Research., Forli S; Department of Integrative Structural and Computational Biology, Scripps Research., Lairson LL; Department of Chemistry, Scripps Research., Ward A; Department of Integrative Structural and Computational Biology, Scripps Research., Parker CG; Department of Chemistry, Scripps Research., Hang HC; Department of Immunology and Microbiology, Scripps Research.; Department of Chemistry, Scripps Research.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 23. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Microbiota-derived secondary bile acids promote STING activation and antitumor activity.
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  Data: <searchLink fieldCode="AU" term="%22Yang+X%22">Yang X</searchLink>; Department of Immunology and Microbiology, Scripps Research.; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Chemical Biology Center, Peking University.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Department of Immunology and Microbiology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Chemistry, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Gharpure+A%22">Gharpure A</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Hansel-Harris+A%22">Hansel-Harris A</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Tillack+AF%22">Tillack AF</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Department of Immunology and Microbiology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Hsieh+YZ%22">Hsieh YZ</searchLink>; Department of Immunology and Microbiology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Sulpizio+A%22">Sulpizio A</searchLink>; Department of Chemistry, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Fam+KT%22">Fam KT</searchLink>; Department of Immunology and Microbiology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Dikiy+S%22">Dikiy S</searchLink>; Department of Immunology and Microbiology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Zhao+X%22">Zhao X</searchLink>; Department of Immunology and Microbiology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Forli+S%22">Forli S</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Lairson+LL%22">Lairson LL</searchLink>; Department of Chemistry, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Ward+A%22">Ward A</searchLink>; Department of Integrative Structural and Computational Biology, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Parker+CG%22">Parker CG</searchLink>; Department of Chemistry, Scripps Research.<br /><searchLink fieldCode="AU" term="%22Hang+HC%22">Hang HC</searchLink>; Department of Immunology and Microbiology, Scripps Research.; Department of Chemistry, Scripps Research.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Oct 23. <i>Date of Electronic Publication: </i>2025 Oct 23.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1101/2025.04.16.649255
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        Text: English
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              Text: 2025 Oct 23
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