View in EDS

Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection.

Saved in:
Bibliographic Details
Title: Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection.
Authors: De Falco A; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy., Grisolia P; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Giuffrida R; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy., Iannarone C; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Graziano C; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy., Scrima M; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy., Cossu AM; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Tufano R; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy., Yow MV; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Brown CM; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA., Bajaj P; Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL., Bocchetti M; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Life Science, Health, and Health Professions, Link University, Rome, Italy., Nuzzo PV; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA., Morgillo F; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Caraglia F; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Delle Corte MC; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Guida GD; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Troiani T; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Ciardiello F; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Rizzo MR; Department of Advanced Clinical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy., Fiorelli A; Thoracic Surgery Unit, University of Campania 'Luigi Vanvitelli', Naples, Italy., Giorgiano NM; Thoracic Surgery Unit, University of Campania 'Luigi Vanvitelli', Naples, Italy., Arcaniolo D; Department of Woman, Child and General and Specialized Surgery and Urology Unit, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy., Rosa GD; Department of Woman, Child and General and Specialized Surgery and Urology Unit, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy., De Sio M; Department of Woman, Child and General and Specialized Surgery and Urology Unit, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy., Covre A; University of Siena, Italy, and Center for Immuno-Oncology, Department of Oncology, University Hospital of Siena, Siena, Italy., Di Giacomo AM; University of Siena, Italy, and Center for Immuno-Oncology, Department of Oncology, University Hospital of Siena, Siena, Italy.; NIBIT Foundation Onlus, Italy., Calabrò L; University of Ferrara, Italy., Fontana P; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy., Mare M; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy., Landgren O; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL., Green DJ; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Division of Transplantation and Cellular Therapy, Department of Medicine, University of Miami, Miami, FL, USA., Lesokhin A; Division of Hematology and Oncology, Memorial Sloan Kettering Cancer Center/Weill Cornell Medical College, New York City, NY, USA., Coffey DG; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL., Merchant N; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Division of Surgical Oncology, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Datta J; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Division of Surgical Oncology, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Forte S; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy., Maio M; University of Siena, Italy, and Center for Immuno-Oncology, Department of Oncology, University Hospital of Siena, Siena, Italy.; NIBIT Foundation Onlus, Italy., Caraglia M; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy., Ceccarelli M; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 21. Date of Electronic Publication: 2025 Oct 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41278930
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22De+Falco+A%22">De Falco A</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.<br /><searchLink fieldCode="AU" term="%22Grisolia+P%22">Grisolia P</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Giuffrida+R%22">Giuffrida R</searchLink>; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy.<br /><searchLink fieldCode="AU" term="%22Iannarone+C%22">Iannarone C</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Graziano+C%22">Graziano C</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.<br /><searchLink fieldCode="AU" term="%22Scrima+M%22">Scrima M</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.<br /><searchLink fieldCode="AU" term="%22Cossu+AM%22">Cossu AM</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Tufano+R%22">Tufano R</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.<br /><searchLink fieldCode="AU" term="%22Yow+MV%22">Yow MV</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Brown+CM%22">Brown CM</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bajaj+P%22">Bajaj P</searchLink>; Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Bocchetti+M%22">Bocchetti M</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Life Science, Health, and Health Professions, Link University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nuzzo+PV%22">Nuzzo PV</searchLink>; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, 10065, USA.<br /><searchLink fieldCode="AU" term="%22Morgillo+F%22">Morgillo F</searchLink>; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Caraglia+F%22">Caraglia F</searchLink>; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Delle+Corte+MC%22">Delle Corte MC</searchLink>; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Guida+GD%22">Guida GD</searchLink>; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Troiani+T%22">Troiani T</searchLink>; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ciardiello+F%22">Ciardiello F</searchLink>; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Rizzo+MR%22">Rizzo MR</searchLink>; Department of Advanced Clinical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Fiorelli+A%22">Fiorelli A</searchLink>; Thoracic Surgery Unit, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Giorgiano+NM%22">Giorgiano NM</searchLink>; Thoracic Surgery Unit, University of Campania 'Luigi Vanvitelli', Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Arcaniolo+D%22">Arcaniolo D</searchLink>; Department of Woman, Child and General and Specialized Surgery and Urology Unit, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.<br /><searchLink fieldCode="AU" term="%22Rosa+GD%22">Rosa GD</searchLink>; Department of Woman, Child and General and Specialized Surgery and Urology Unit, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.<br /><searchLink fieldCode="AU" term="%22De+Sio+M%22">De Sio M</searchLink>; Department of Woman, Child and General and Specialized Surgery and Urology Unit, University of Campania 'Luigi Vanvitelli', Naples, 80138, Italy.<br /><searchLink fieldCode="AU" term="%22Covre+A%22">Covre A</searchLink>; University of Siena, Italy, and Center for Immuno-Oncology, Department of Oncology, University Hospital of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Giacomo+AM%22">Di Giacomo AM</searchLink>; University of Siena, Italy, and Center for Immuno-Oncology, Department of Oncology, University Hospital of Siena, Siena, Italy.; NIBIT Foundation Onlus, Italy.<br /><searchLink fieldCode="AU" term="%22Calabrò+L%22">Calabrò L</searchLink>; University of Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Fontana+P%22">Fontana P</searchLink>; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy.<br /><searchLink fieldCode="AU" term="%22Mare+M%22">Mare M</searchLink>; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy.<br /><searchLink fieldCode="AU" term="%22Landgren+O%22">Landgren O</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Green+DJ%22">Green DJ</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Division of Transplantation and Cellular Therapy, Department of Medicine, University of Miami, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Lesokhin+A%22">Lesokhin A</searchLink>; Division of Hematology and Oncology, Memorial Sloan Kettering Cancer Center/Weill Cornell Medical College, New York City, NY, USA.<br /><searchLink fieldCode="AU" term="%22Coffey+DG%22">Coffey DG</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Myeloma Division, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL.<br /><searchLink fieldCode="AU" term="%22Merchant+N%22">Merchant N</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Division of Surgical Oncology, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Datta+J%22">Datta J</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Division of Surgical Oncology, Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.<br /><searchLink fieldCode="AU" term="%22Forte+S%22">Forte S</searchLink>; Istituto Oncologico del Mediterraneo, Viagrande (CT), Italy.<br /><searchLink fieldCode="AU" term="%22Maio+M%22">Maio M</searchLink>; University of Siena, Italy, and Center for Immuno-Oncology, Department of Oncology, University Hospital of Siena, Siena, Italy.; NIBIT Foundation Onlus, Italy.<br /><searchLink fieldCode="AU" term="%22Caraglia+M%22">Caraglia M</searchLink>; BIOGEM Institute of Molecular Biology and Genetics, Ariano Irpino, Italy.; Department of Precision Medicine, University of Campania 'L. Vanvitelli', 80138 Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ceccarelli+M%22">Ceccarelli M</searchLink>; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL, USA.; Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Oct 21. <i>Date of Electronic Publication: </i>2025 Oct 21.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Preprint
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41278930
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1101/2025.10.20.683167
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detection.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: De Falco A
      – PersonEntity:
          Name:
            NameFull: Grisolia P
      – PersonEntity:
          Name:
            NameFull: Giuffrida R
      – PersonEntity:
          Name:
            NameFull: Iannarone C
      – PersonEntity:
          Name:
            NameFull: Graziano C
      – PersonEntity:
          Name:
            NameFull: Scrima M
      – PersonEntity:
          Name:
            NameFull: Cossu AM
      – PersonEntity:
          Name:
            NameFull: Tufano R
      – PersonEntity:
          Name:
            NameFull: Yow MV
      – PersonEntity:
          Name:
            NameFull: Brown CM
      – PersonEntity:
          Name:
            NameFull: Bajaj P
      – PersonEntity:
          Name:
            NameFull: Bocchetti M
      – PersonEntity:
          Name:
            NameFull: Nuzzo PV
      – PersonEntity:
          Name:
            NameFull: Morgillo F
      – PersonEntity:
          Name:
            NameFull: Caraglia F
      – PersonEntity:
          Name:
            NameFull: Delle Corte MC
      – PersonEntity:
          Name:
            NameFull: Guida GD
      – PersonEntity:
          Name:
            NameFull: Troiani T
      – PersonEntity:
          Name:
            NameFull: Ciardiello F
      – PersonEntity:
          Name:
            NameFull: Rizzo MR
      – PersonEntity:
          Name:
            NameFull: Fiorelli A
      – PersonEntity:
          Name:
            NameFull: Giorgiano NM
      – PersonEntity:
          Name:
            NameFull: Arcaniolo D
      – PersonEntity:
          Name:
            NameFull: Rosa GD
      – PersonEntity:
          Name:
            NameFull: De Sio M
      – PersonEntity:
          Name:
            NameFull: Covre A
      – PersonEntity:
          Name:
            NameFull: Di Giacomo AM
      – PersonEntity:
          Name:
            NameFull: Calabrò L
      – PersonEntity:
          Name:
            NameFull: Fontana P
      – PersonEntity:
          Name:
            NameFull: Mare M
      – PersonEntity:
          Name:
            NameFull: Landgren O
      – PersonEntity:
          Name:
            NameFull: Green DJ
      – PersonEntity:
          Name:
            NameFull: Lesokhin A
      – PersonEntity:
          Name:
            NameFull: Coffey DG
      – PersonEntity:
          Name:
            NameFull: Merchant N
      – PersonEntity:
          Name:
            NameFull: Datta J
      – PersonEntity:
          Name:
            NameFull: Forte S
      – PersonEntity:
          Name:
            NameFull: Maio M
      – PersonEntity:
          Name:
            NameFull: Caraglia M
      – PersonEntity:
          Name:
            NameFull: Ceccarelli M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 21
              M: 10
              Text: 2025 Oct 21
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1