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Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design.

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Title: Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design.
Authors: Skelly AN; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Gristick HB; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Li H; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Gavor E; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Connell AJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Kreider EF; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia; PA 19104, USA., Marchitto L; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Hogarty MP; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Newby ML; School of Biological Sciences, University of Southampton; Southampton SO17 1BJ, UK., Allen JD; School of Biological Sciences, University of Southampton; Southampton SO17 1BJ, UK., Liu W; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., West AP Jr; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Ayyanathan K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Campion MS; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Winters K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Gordon CG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Osbaldeston RA; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Akeley MJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Li Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Singh A; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Cruickshank K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Park Y; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Zhao C; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Li X; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Amereh K; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Itallie EV; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine; Durham, NC 27710, USA., Carey JW; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Albertus A; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia; PA 19104, USA., DeLaitsch AT; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Keeffe JR; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Lituchy MG; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Walsh AA; Department of Immunology and Microbiology, Scripps Research Institute; La Jolla, CA 92037, USA., Morris DJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Habib R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Bibollet-Ruche F; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Mishra N; Department of Immunology and Microbiology, Scripps Research Institute; La Jolla, CA 92037, USA., Avillion G; Department of Immunology and Microbiology, Scripps Research Institute; La Jolla, CA 92037, USA., Koranda NS; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Plante SJ; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Martella CL; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Lora J; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Wang EJD; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Lewis MG; Bioqual, Inc.; Rockville, MD 20850, USA., Martin MA; Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD 20892, USA., Nussenzweig MC; Laboratory of Molecular Immunology, Rockefeller University; New York, NY 10065, USA.; Howard Hughes Medical Institute, Rockefeller University; New York, NY 10065, USA., Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center; Boston, MA 02215, USA., Irvine DJ; Department of Immunology and Microbiology, Scripps Research Institute; La Jolla, CA 92037, USA.; Howard Hughes Medical Institute; Chevy Chase, MD, USA., Wiehe KJ; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine; Durham, NC 27710, USA., Haynes BF; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine; Durham, NC 27710, USA., Wagh K; Duke Human Vaccine Institute and Department of Medicine, Duke University School of Medicine; Durham, NC 27710, USA., Korber BT; Los Alamos National Laboratory; Los Alamos, NM 87545, USA.; New Mexico Consortium; Los Alamos, NM 87545, USA., Andrabi R; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Crispin M; School of Biological Sciences, University of Southampton; Southampton SO17 1BJ, UK., Weissman D; Penn Institute for RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia; PA 19104, USA., Bjorkman PJ; Division of Biology and Biological Engineering, California Institute of Technology; Pasadena, CA 91125, USA., Hahn BH; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA., Shaw GM; Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania; Philadelphia, PA 19104, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 06. Date of Electronic Publication: 2025 Oct 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design.
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      – PersonEntity:
          Name:
            NameFull: Crispin M
      – PersonEntity:
          Name:
            NameFull: Weissman D
      – PersonEntity:
          Name:
            NameFull: Bjorkman PJ
      – PersonEntity:
          Name:
            NameFull: Hahn BH
      – PersonEntity:
          Name:
            NameFull: Shaw GM
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 06
              M: 10
              Text: 2025 Oct 06
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1