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Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site.

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Title: Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site.
Authors: Wang L; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Joseph J; Department of Immunology and Infectious Diseases; Harvard T.H. Chan School of Public Health; Boston, Massachusetts, 02115; United States of America., Vasquez S; Department of Biology; Stanford University; Stanford, CA, 94305; United States of America., Wrapp D; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America.; Current affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710; United States of America., Sheahan TP; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Dzuvor CKO; Department of Immunology and Infectious Diseases; Harvard T.H. Chan School of Public Health; Boston, Massachusetts, 02115; United States of America., Rosen O; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Current affiliation: Department of Biotechnology, Israel Institute for Biological Research, Ness-Ziona, Israel., Kirchdoerfer RN; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA,92037; United States of America.; Current affiliation: Department of Biochemistry, Institute for Molecular Virology, Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, 53706; United States of America., Abiona OM; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Hammond C; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; United States of America., Shi W; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Moak SP; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; United States of America., Kong WP; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Zhang Y; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Eso MR; Department of Biology; Stanford University; Stanford, CA, 94305; United States of America., Brown AJ; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA,92037; United States of America., Baric R; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America., McLellan JS; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America., Pierson TC; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America., Mascola J; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Current affiliation: Modex Therapeutics, Weston, MA, 02493., Graham BS; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Current affiliation: Medicine and Microbiology, Biochemistry, & Immunology, Morehouse School of Medicine, Atlanta, GA, 30310., Yassine HM; Biomedical Research Center, Member of QU Health, Qatar University; Doha, Qatar., Barnes CO; Department of Biology; Stanford University; Stanford, CA, 94305; United States of America.; ChEM-H Institute, Stanford University; Stanford, 94305, United States of America.; Chan Zuckerberg Biohub; San Francisco, 94158, United States of America., Corbett-Helaire KS; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Department of Immunology and Infectious Diseases; Harvard T.H. Chan School of Public Health; Boston, Massachusetts, 02115; United States of America.; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; United States of America.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 30. Date of Electronic Publication: 2025 Oct 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Human Coronavirus HKU1 Neutralizing Monoclonal Antibodies Target Diverse Epitopes Within and Around the TMPRSS2 Receptor Binding Site.
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  Data: <searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.<br /><searchLink fieldCode="AU" term="%22Joseph+J%22">Joseph J</searchLink>; Department of Immunology and Infectious Diseases; Harvard T.H. Chan School of Public Health; Boston, Massachusetts, 02115; United States of America.<br /><searchLink fieldCode="AU" term="%22Vasquez+S%22">Vasquez S</searchLink>; Department of Biology; Stanford University; Stanford, CA, 94305; United States of America.<br /><searchLink fieldCode="AU" term="%22Wrapp+D%22">Wrapp D</searchLink>; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America.; Current affiliation: Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710; United States of America.<br /><searchLink fieldCode="AU" term="%22Sheahan+TP%22">Sheahan TP</searchLink>; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America.<br /><searchLink fieldCode="AU" term="%22Dzuvor+CKO%22">Dzuvor CKO</searchLink>; Department of Immunology and Infectious Diseases; Harvard T.H. Chan School of Public Health; Boston, Massachusetts, 02115; United States of America.<br /><searchLink fieldCode="AU" term="%22Rosen+O%22">Rosen O</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Current affiliation: Department of Biotechnology, Israel Institute for Biological Research, Ness-Ziona, Israel.<br /><searchLink fieldCode="AU" term="%22Kirchdoerfer+RN%22">Kirchdoerfer RN</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA,92037; United States of America.; Current affiliation: Department of Biochemistry, Institute for Molecular Virology, Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, Wisconsin, 53706; United States of America.<br /><searchLink fieldCode="AU" term="%22Abiona+OM%22">Abiona OM</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.<br /><searchLink fieldCode="AU" term="%22Hammond+C%22">Hammond C</searchLink>; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; United States of America.<br /><searchLink fieldCode="AU" term="%22Shi+W%22">Shi W</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.<br /><searchLink fieldCode="AU" term="%22Moak+SP%22">Moak SP</searchLink>; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; United States of America.<br /><searchLink fieldCode="AU" term="%22Kong+WP%22">Kong WP</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.<br /><searchLink fieldCode="AU" term="%22Eso+MR%22">Eso MR</searchLink>; Department of Biology; Stanford University; Stanford, CA, 94305; United States of America.<br /><searchLink fieldCode="AU" term="%22Brown+AJ%22">Brown AJ</searchLink>; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America.<br /><searchLink fieldCode="AU" term="%22Ward+AB%22">Ward AB</searchLink>; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA,92037; United States of America.<br /><searchLink fieldCode="AU" term="%22Baric+R%22">Baric R</searchLink>; Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill, North Carolina, 27599; United States of America.<br /><searchLink fieldCode="AU" term="%22McLellan+JS%22">McLellan JS</searchLink>; Department of Molecular Biosciences; University of Texas at Austin; Austin, Texas, 78712; United States of America.<br /><searchLink fieldCode="AU" term="%22Pierson+TC%22">Pierson TC</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.<br /><searchLink fieldCode="AU" term="%22Mascola+J%22">Mascola J</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Current affiliation: Modex Therapeutics, Weston, MA, 02493.<br /><searchLink fieldCode="AU" term="%22Graham+BS%22">Graham BS</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Current affiliation: Medicine and Microbiology, Biochemistry, & Immunology, Morehouse School of Medicine, Atlanta, GA, 30310.<br /><searchLink fieldCode="AU" term="%22Yassine+HM%22">Yassine HM</searchLink>; Biomedical Research Center, Member of QU Health, Qatar University; Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Barnes+CO%22">Barnes CO</searchLink>; Department of Biology; Stanford University; Stanford, CA, 94305; United States of America.; ChEM-H Institute, Stanford University; Stanford, 94305, United States of America.; Chan Zuckerberg Biohub; San Francisco, 94158, United States of America.<br /><searchLink fieldCode="AU" term="%22Corbett-Helaire+KS%22">Corbett-Helaire KS</searchLink>; Vaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892; United States of America.; Department of Immunology and Infectious Diseases; Harvard T.H. Chan School of Public Health; Boston, Massachusetts, 02115; United States of America.; Howard Hughes Medical Institute; Chevy Chase, Maryland, 20815; United States of America.
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