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Acetoacetate suppresses colon cancer via an MR1-MAIT axis.

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Title: Acetoacetate suppresses colon cancer via an MR1-MAIT axis.
Authors: Clay SL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Tekle GE; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Rashan EH; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Fonseca-Pereira D; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Shin YH; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA., Andreeva N; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Nakatsu G; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Current address: R&D Laboratory, Ezaki Glico Co. Ltd., Osaka, Japan., Lobo AF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Current address: Yale University School of Medicine, New Haven, CT, USA., Chen SP; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Massachusetts General Hospital, Boston, MA, USA., Bae S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Michaud M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Glickman JN; Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA., Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA., Vander Heiden MG; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Garrett WS; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 01. Date of Electronic Publication: 2025 Nov 01.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Acetoacetate suppresses colon cancer via an MR1-MAIT axis.
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  Data: <searchLink fieldCode="AU" term="%22Clay+SL%22">Clay SL</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Tekle+GE%22">Tekle GE</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Rashan+EH%22">Rashan EH</searchLink>; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fonseca-Pereira+D%22">Fonseca-Pereira D</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Shin+YH%22">Shin YH</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Andreeva+N%22">Andreeva N</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nakatsu+G%22">Nakatsu G</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Current address: R&D Laboratory, Ezaki Glico Co. Ltd., Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Lobo+AF%22">Lobo AF</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Current address: Yale University School of Medicine, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Chen+SP%22">Chen SP</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Massachusetts General Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bae+S%22">Bae S</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Michaud+M%22">Michaud M</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Glickman+JN%22">Glickman JN</searchLink>; Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Clardy+J%22">Clardy J</searchLink>; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+MG%22">Vander Heiden MG</searchLink>; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Garrett+WS%22">Garrett WS</searchLink>; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
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        Value: 10.1101/2025.10.29.685375
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              Text: 2025 Nov 01
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