Acetoacetate suppresses colon cancer via an MR1-MAIT axis.
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| Title: | Acetoacetate suppresses colon cancer via an MR1-MAIT axis. |
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| Authors: | Clay SL; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Tekle GE; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Rashan EH; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Fonseca-Pereira D; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Shin YH; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA., Andreeva N; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Nakatsu G; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Current address: R&D Laboratory, Ezaki Glico Co. Ltd., Osaka, Japan., Lobo AF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Current address: Yale University School of Medicine, New Haven, CT, USA., Chen SP; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Massachusetts General Hospital, Boston, MA, USA., Bae S; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Michaud M; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA., Glickman JN; Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA., Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School and Blavatnik Institute, Boston, MA, USA., Vander Heiden MG; The David H. Koch Institute for Integrative Cancer Research and the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA., Garrett WS; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.; Harvard T.H. Chan Microbiome in Public Health Center, Boston, Massachusetts, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. |
| Source: | BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 01. Date of Electronic Publication: 2025 Nov 01. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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