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Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell type abundance and fiber-type-level gene expression.

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Title: Inverse directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell type abundance and fiber-type-level gene expression.
Authors: Ciotlos DL; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Hanks SC; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Varshney A; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Erdos MR; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Manickam N; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Stringham HM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Orchard P; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA., Hill-Burns EM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Narisu N; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Bonnycastle LL; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Sweeney MD; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Saramies J; South Karelia Social and Health Care District, Wellbeing Services County of South Karelia, South Karelia, Finland., Laakso M; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland., Tuomilehto J; Department of Public Health, University of Helsinki, Helsinki, Finland., Lakka TA; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA., Koistinen HA; University of Helsinki, Faculty of Medicine, Research Programs Unit, Clinical and Molecular Metabolism (CAMM), Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Parker SCJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA., Scott LJ; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 28. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Ciotlos+DL%22">Ciotlos DL</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Hanks+SC%22">Hanks SC</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Varshney+A%22">Varshney A</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Erdos+MR%22">Erdos MR</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Manickam+N%22">Manickam N</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Stringham+HM%22">Stringham HM</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Orchard+P%22">Orchard P</searchLink>; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Hill-Burns+EM%22">Hill-Burns EM</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Narisu+N%22">Narisu N</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Bonnycastle+LL%22">Bonnycastle LL</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Sweeney+MD%22">Sweeney MD</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Saramies+J%22">Saramies J</searchLink>; South Karelia Social and Health Care District, Wellbeing Services County of South Karelia, South Karelia, Finland.<br /><searchLink fieldCode="AU" term="%22Laakso+M%22">Laakso M</searchLink>; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Tuomilehto+J%22">Tuomilehto J</searchLink>; Department of Public Health, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Lakka+TA%22">Lakka TA</searchLink>; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland.; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.<br /><searchLink fieldCode="AU" term="%22Mohlke+KL%22">Mohlke KL</searchLink>; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Collins+FS%22">Collins FS</searchLink>; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Koistinen+HA%22">Koistinen HA</searchLink>; University of Helsinki, Faculty of Medicine, Research Programs Unit, Clinical and Molecular Metabolism (CAMM), Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Parker+SCJ%22">Parker SCJ</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.; Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Scott+LJ%22">Scott LJ</searchLink>; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
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