Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans.

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Title: Intraspecific sequence variation and complete genomes refine the identification of rapidly evolved regions in humans.
Authors: Luo Y; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.; Department of Cell Biology, Duke University, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.; These authors contributed equally to this work., Mangan RJ; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA.; Genetics Training Program, Harvard Medical School, 25 Shattuck St, Boston MA, 02115, USA.; These authors contributed equally to this work., Weaver S; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.; Department of Cell Biology, Duke University, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA., Zhao SA; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Mosti F; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.; Department of Cell Biology, Duke University, Durham, NC 27710, USA.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA., Thomas MC; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Karra R; Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA., Silver DL; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.; Department of Cell Biology, Duke University, Durham, NC 27710, USA.; Duke Institute for Brain Sciences and Duke Regeneration Center, Duke University Medical Center, Durham, NC 27710, USA.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA., Kellis M; Computer Science and Artificial Intelligence Lab, Massachusetts Institute of Technology, 32 Vassar St, Cambridge, MA 02139, USA.; The Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, MA 02142, USA., Lowe CB; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC 27710, USA.; Department of Cell Biology, Duke University, Durham, NC 27710, USA.; University Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.; Lead contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 21. Date of Electronic Publication: 2025 Oct 21.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2692-8205
DOI:10.1101/2025.10.20.683446