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Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.

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Title: Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.
Authors: Mishra N; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Liang B; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Roark RS; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Ghosh A; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA., Callaghan S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Lee WH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA., Li X; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Vo AL; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Avillion G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Chowdhury RR; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Habib RH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Bibollet-Ruche F; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Giese G; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Oberoi P; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Amereh K; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Somanathan A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhu Y; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Zhang Y; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Kassab M; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Tjio L; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Andrabi S; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Reyes RA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA., Allen JD; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., James NE; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Randall KN Jr; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA., van der Maas L; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA., Ben-Akiva E; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Kacmarek-Michaels K; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139., Plante S; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Martella CL; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Skelly AN; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Singh A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA., Hurtado J; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Dueker K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Capozzola T; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Nedellec R; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA., Lewis MM; Bioqual, Inc., Rockville, Maryland, USA., Falcone S; Moderna, Inc., Cambridge, Ma 02139, USA., Carfi A; Moderna, Inc., Cambridge, Ma 02139, USA., Himansu S; Moderna, Inc., Cambridge, Ma 02139, USA., Shapiro L; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Crispin M; School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK., Hahn BH; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Briney B; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA., Irvine DJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815., Burton DR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Ward AB; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 28 92037, USA.; IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA., Batista FD; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kwong PD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA., Shaw GM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Andrabi R; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Lead Contact.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 23. Date of Electronic Publication: 2025 Oct 23.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques.
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  Data: <searchLink fieldCode="AU" term="%22Mishra+N%22">Mishra N</searchLink>; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.; Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Liang+B%22">Liang B</searchLink>; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.<br /><searchLink fieldCode="AU" term="%22Roark+RS%22">Roark RS</searchLink>; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Ghosh+A%22">Ghosh A</searchLink>; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02114, USA.<br /><searchLink fieldCode="AU" term="%22Callaghan+S%22">Callaghan S</searchLink>; 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      – PersonEntity:
          Name:
            NameFull: Hurtado J
      – PersonEntity:
          Name:
            NameFull: Dueker K
      – PersonEntity:
          Name:
            NameFull: Capozzola T
      – PersonEntity:
          Name:
            NameFull: Nedellec R
      – PersonEntity:
          Name:
            NameFull: Ozorowski G
      – PersonEntity:
          Name:
            NameFull: Lewis MM
      – PersonEntity:
          Name:
            NameFull: Falcone S
      – PersonEntity:
          Name:
            NameFull: Carfi A
      – PersonEntity:
          Name:
            NameFull: Himansu S
      – PersonEntity:
          Name:
            NameFull: Shapiro L
      – PersonEntity:
          Name:
            NameFull: Crispin M
      – PersonEntity:
          Name:
            NameFull: Hahn BH
      – PersonEntity:
          Name:
            NameFull: Briney B
      – PersonEntity:
          Name:
            NameFull: Irvine DJ
      – PersonEntity:
          Name:
            NameFull: Burton DR
      – PersonEntity:
          Name:
            NameFull: Ward AB
      – PersonEntity:
          Name:
            NameFull: Batista FD
      – PersonEntity:
          Name:
            NameFull: Kwong PD
      – PersonEntity:
          Name:
            NameFull: Shaw GM
      – PersonEntity:
          Name:
            NameFull: Andrabi R
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 23
              M: 10
              Text: 2025 Oct 23
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2692-8205
          Titles:
            – TitleFull: BioRxiv : the preprint server for biology
              Type: main
ResultId 1