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High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists.

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Title: High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists.
Authors: Abedi M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Expòsit M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Coventry B; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Mathew D; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.; Institute for Immunology and Immune Health, University of Pennsylvania School of Medicine,Pennsylvania, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA., Jain S; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Krishnakumar A; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Goreshnik I; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Gray-Gaillard SL; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.; Institute for Immunology and Immune Health, University of Pennsylvania School of Medicine,Pennsylvania, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA., Lunn-Halbert M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Yu TY; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Glögl M; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Mitchell U; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Keshri R; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA., Chun JH; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA., Ruohola-Baker H; Department of Oral Health Sciences, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA.; Institute on Human Development and Disability, University of Washington, Seattle, WA, USA., Wherry EJ; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.; Institute for Immunology and Immune Health, University of Pennsylvania School of Medicine,Pennsylvania, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 13. Date of Electronic Publication: 2025 Oct 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists.
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  Data: <searchLink fieldCode="AU" term="%22Abedi+M%22">Abedi M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Expòsit+M%22">Expòsit M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Coventry+B%22">Coventry B</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mathew+D%22">Mathew D</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.; Institute for Immunology and Immune Health, University of Pennsylvania School of Medicine,Pennsylvania, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Jain+S%22">Jain S</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Krishnakumar+A%22">Krishnakumar A</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Goreshnik+I%22">Goreshnik I</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gray-Gaillard+SL%22">Gray-Gaillard SL</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.; Institute for Immunology and Immune Health, University of Pennsylvania School of Medicine,Pennsylvania, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Lunn-Halbert+M%22">Lunn-Halbert M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Yu+TY%22">Yu TY</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Glögl+M%22">Glögl M</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+U%22">Mitchell U</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Keshri+R%22">Keshri R</searchLink>; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Chun+JH%22">Chun JH</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Ruohola-Baker+H%22">Ruohola-Baker H</searchLink>; Department of Oral Health Sciences, University of Washington, Seattle, WA, USA.; Department of Biochemistry, University of Washington School of Medicine, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA, USA.; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA.; Institute on Human Development and Disability, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Wherry+EJ%22">Wherry EJ</searchLink>; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.; Institute for Immunology and Immune Health, University of Pennsylvania School of Medicine,Pennsylvania, PA, USA.; Colton Center for Autoimmunity, University of Pennsylvania School of Medicine, Pennsylvania, PA, USA.<br /><searchLink fieldCode="AU" term="%22Baker+D%22">Baker D</searchLink>; Department of Biochemistry, University of Washington, Seattle, WA, USA.; Institute for Protein Design, University of Washington, Seattle, WA, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
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