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Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.

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Title: Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.
Authors: Handklo-Jamal R; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Raifman TK; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Shalomov B; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Hofer P; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria., Kahanovitch U; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Friesacher T; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria., Tabak G; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Tsemakhovich V; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Reddy HP; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel., Chomsky-Hecht O; Department of Biochemistry & Molecular Biology, School of Neurobiology, Biochemistry and Biophysics, George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Tripathy DR; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Biochemistry & Molecular Biology, School of Neurobiology, Biochemistry and Biophysics, George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Zuhlke K; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Dessauer CW; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, USA., Klussmann E; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany., Haitin Y; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel., Hirsch JA; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Biochemistry & Molecular Biology, School of Neurobiology, Biochemistry and Biophysics, George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel., Stary-Weinzinger A; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria., Yakubovich D; The Adelson School of Medicine, Ariel University, Ariel 4077625, Israel., Dascal N; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 15. Date of Electronic Publication: 2025 Oct 15.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Live-cell quantitative monitoring reveals distinct, high-affinity Gβγ regulations of GIRK2 and GIRK1/2 channels.
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  Data: <searchLink fieldCode="AU" term="%22Handklo-Jamal+R%22">Handklo-Jamal R</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Raifman+TK%22">Raifman TK</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Shalomov+B%22">Shalomov B</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Hofer+P%22">Hofer P</searchLink>; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Kahanovitch+U%22">Kahanovitch U</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Friesacher+T%22">Friesacher T</searchLink>; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Tabak+G%22">Tabak G</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Tsemakhovich+V%22">Tsemakhovich V</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Reddy+HP%22">Reddy HP</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Chomsky-Hecht+O%22">Chomsky-Hecht O</searchLink>; Department of Biochemistry & Molecular Biology, School of Neurobiology, Biochemistry and Biophysics, George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Tripathy+DR%22">Tripathy DR</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.; Department of Biochemistry & Molecular Biology, School of Neurobiology, Biochemistry and Biophysics, George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Zuhlke+K%22">Zuhlke K</searchLink>; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Dessauer+CW%22">Dessauer CW</searchLink>; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Klussmann+E%22">Klussmann E</searchLink>; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Haitin+Y%22">Haitin Y</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Hirsch+JA%22">Hirsch JA</searchLink>; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.; Department of Biochemistry & Molecular Biology, School of Neurobiology, Biochemistry and Biophysics, George S. Weiss Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Stary-Weinzinger+A%22">Stary-Weinzinger A</searchLink>; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Yakubovich+D%22">Yakubovich D</searchLink>; The Adelson School of Medicine, Ariel University, Ariel 4077625, Israel.<br /><searchLink fieldCode="AU" term="%22Dascal+N%22">Dascal N</searchLink>; Department of Physiology and Pharmacology, Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel.; Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel.
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