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Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells.

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Title: Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells.
Authors: Charles AM; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Rodhouse CE; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Darden DB; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Gauthier ML; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States., Zhou M; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.; Present address: Jinhua Academy, Zhejiang Chinese Medical University, Jinhua, Zhejiang Province, 321032, China., Hernandez-Rios M; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Wang D; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States., Casadesus G; Department of Pharmacy and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA., Bible L; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Mohr AM; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Xiao F; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Cai G; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Brant JO; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States., Wallet SM; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, United States., Mathews CE; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA., Moldawer LL; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Chakrabarty P; Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida, USA., Bacher RL; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States., Efron PA; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Maile R; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States., Kladde MP; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, United States.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 16. Date of Electronic Publication: 2025 Oct 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells.
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  Data: <searchLink fieldCode="AU" term="%22Charles+AM%22">Charles AM</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Rodhouse+CE%22">Rodhouse CE</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Darden+DB%22">Darden DB</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Gauthier+ML%22">Gauthier ML</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.; Present address: Jinhua Academy, Zhejiang Chinese Medical University, Jinhua, Zhejiang Province, 321032, China.<br /><searchLink fieldCode="AU" term="%22Hernandez-Rios+M%22">Hernandez-Rios M</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Casadesus+G%22">Casadesus G</searchLink>; Department of Pharmacy and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Bible+L%22">Bible L</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Mohr+AM%22">Mohr AM</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Xiao+F%22">Xiao F</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Cai+G%22">Cai G</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Brant+JO%22">Brant JO</searchLink>; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Wallet+SM%22">Wallet SM</searchLink>; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Mathews+CE%22">Mathews CE</searchLink>; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Moldawer+LL%22">Moldawer LL</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Chakrabarty+P%22">Chakrabarty P</searchLink>; Department of Neuroscience, University of Florida College of Medicine, Gainesville, Florida, USA.<br /><searchLink fieldCode="AU" term="%22Bacher+RL%22">Bacher RL</searchLink>; Department of Biostatistics, College of Public Health & Health Professions, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Efron+PA%22">Efron PA</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Maile+R%22">Maile R</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.<br /><searchLink fieldCode="AU" term="%22Kladde+MP%22">Kladde MP</searchLink>; Sepsis and Critical Illness Research Center, Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States.; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida, United States.; Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, United States.
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