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The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.

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Title: The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.
Authors: Liu AZ; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore., Narkar A; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Li K; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore., Bertomeu T; The ChemoGenix CRISPR screening facility of the Institute for Research in Immunology and Cancer, University of Montreal, 2950 Chemin de Polytechnique, Montréal, QC H3T 1J4, Canada., Johnson BA; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Coulombe-Huntington J; Department of Bioengineering, McGill University, Montreal, QC H3A 0E9, Canada., Dong Y; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA., Zhu J; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore., Tyers M; Department of Molecular Genetics, University of Toronto; Toronto, Ontario M5S 1A8, Canada.; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada., Li R; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Dec 29. Date of Electronic Publication: 2025 Dec 29.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Liu+AZ%22">Liu AZ</searchLink>; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.<br /><searchLink fieldCode="AU" term="%22Narkar+A%22">Narkar A</searchLink>; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.<br /><searchLink fieldCode="AU" term="%22Bertomeu+T%22">Bertomeu T</searchLink>; The ChemoGenix CRISPR screening facility of the Institute for Research in Immunology and Cancer, University of Montreal, 2950 Chemin de Polytechnique, Montréal, QC H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Johnson+BA%22">Johnson BA</searchLink>; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Coulombe-Huntington+J%22">Coulombe-Huntington J</searchLink>; Department of Bioengineering, McGill University, Montreal, QC H3A 0E9, Canada.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Department of Molecular Genetics, University of Toronto; Toronto, Ontario M5S 1A8, Canada.; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Li+R%22">Li R</searchLink>; Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Mechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.; Department of Biological Sciences, National University of Singapore, Singapore 117558, Singapore.
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  Data: <searchLink fieldCode="JN" term="%22101680187%22">BioRxiv : the preprint server for biology</searchLink> [bioRxiv] 2025 Dec 29. <i>Date of Electronic Publication: </i>2025 Dec 29.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101680187 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2692-8205 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226928205%22">26928205 </searchLink><i>NLM ISO Abbreviation: </i>bioRxiv <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.1101/2025.11.04.686150
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        Text: English
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      – TitleFull: The scaffold protein PRR14L links the PP2A-TACC3 axis to mitotic fidelity and sensitivity to MPS1 inhibition.
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            – D: 29
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              Text: 2025 Dec 29
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