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Iterative immunogen optimization to focus immune responses on a conserved, subdominant viral epitope.

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Title: Iterative immunogen optimization to focus immune responses on a conserved, subdominant viral epitope.
Authors: Marston DJ; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC., Watanabe A; Department of Integrative Immunology, Duke University, Durham, NC, USA., Kapingidza AB; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC., Harris C; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC., Van Itallie E; Duke Human Vaccine Institute, Duke University, Durham, NC., Devkota K; Department of Cell Biology, Duke University, Durham, NC.; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC., Christopher J; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC., Liu P; Department of Integrative Immunology, Duke University, Durham, NC, USA., Pun B; Department of Integrative Immunology, Duke University, Durham, NC, USA., Rhodes B; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC., Frazier M; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC., Winters K; Duke University, Durham, NC., Burre H; Duke University, Durham, NC., Kannan P; Duke University, Durham, NC., Liang X; Department of Integrative Immunology, Duke University, Durham, NC, USA., Kelsoe G; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Integrative Immunology, Duke University, Durham, NC, USA.; Department of Surgery, Duke University, Durham, NC., Wiehe K; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Medicine, Duke University School of Medicine, Durham, NC., Singh R; Department of Cell Biology, Duke University, Durham, NC.; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC., Wrapp D; Duke Human Vaccine Institute, Duke University, Durham, NC., Kuraoka M; Department of Integrative Immunology, Duke University, Durham, NC, USA., Azoitei ML; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Nov 06. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Iterative immunogen optimization to focus immune responses on a conserved, subdominant viral epitope.
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  Data: <searchLink fieldCode="AU" term="%22Marston+DJ%22">Marston DJ</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Watanabe+A%22">Watanabe A</searchLink>; Department of Integrative Immunology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kapingidza+AB%22">Kapingidza AB</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Harris+C%22">Harris C</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Van+Itallie+E%22">Van Itallie E</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Devkota+K%22">Devkota K</searchLink>; Department of Cell Biology, Duke University, Durham, NC.; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Christopher+J%22">Christopher J</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; Department of Integrative Immunology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Pun+B%22">Pun B</searchLink>; Department of Integrative Immunology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Rhodes+B%22">Rhodes B</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Frazier+M%22">Frazier M</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Winters+K%22">Winters K</searchLink>; Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Burre+H%22">Burre H</searchLink>; Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Kannan+P%22">Kannan P</searchLink>; Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Liang+X%22">Liang X</searchLink>; Department of Integrative Immunology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Kelsoe+G%22">Kelsoe G</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Integrative Immunology, Duke University, Durham, NC, USA.; Department of Surgery, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Wiehe+K%22">Wiehe K</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Medicine, Duke University School of Medicine, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Singh+R%22">Singh R</searchLink>; Department of Cell Biology, Duke University, Durham, NC.; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Wrapp+D%22">Wrapp D</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.<br /><searchLink fieldCode="AU" term="%22Kuraoka+M%22">Kuraoka M</searchLink>; Department of Integrative Immunology, Duke University, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Azoitei+ML%22">Azoitei ML</searchLink>; Duke Human Vaccine Institute, Duke University, Durham, NC.; Department of Cell Biology, Duke University, Durham, NC.
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