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Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies.

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Title: Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies.
Authors: Manabe T; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Bergo HC; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Li Q; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Wang TS; Kinnate Biopharma, San Diego, CA, 92130, USA., Severson P; Kinnate Biopharma, San Diego, CA, 92130, USA., Miller N; Kinnate Biopharma, San Diego, CA, 92130, USA., Lee C; Kinnate Biopharma, San Diego, CA, 92130, USA., Donderici EY; Guardant Health, Redwood City, CA, 64063, USA., Zhang N; Guardant Health, Redwood City, CA, 64063, USA., Wu W; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Chou YT; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Kerr DL; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Allegakoen P; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA., Grandinetti KB; Kinnate Biopharma, San Diego, CA, 92130, USA., Soroceanu L; Kinnate Biopharma, San Diego, CA, 92130, USA., Pelham RJ; Kinnate Biopharma, San Diego, CA, 92130, USA., Martin ES; Kinnate Biopharma, San Diego, CA, 92130, USA., Murphy EA; Kinnate Biopharma, San Diego, CA, 92130, USA., Khanna V; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Neal JW; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Chen CT; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA., Kato S; Division of Hematology and Oncology, University of California San Diego, Moores Cancer Center, La Jolla, CA, 92093, USA., Williams R; Kinnate Biopharma, San Diego, CA, 92130, USA., Bivona TG; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.
Source: Research square [Res Sq] 2025 Oct 09. Date of Electronic Publication: 2025 Oct 09.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
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  Data: Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies.
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  Data: <searchLink fieldCode="AU" term="%22Manabe+T%22">Manabe T</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Bergo+HC%22">Bergo HC</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Li+Q%22">Li Q</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; 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Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Chou+YT%22">Chou YT</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Kerr+DL%22">Kerr DL</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; 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Kinnate Biopharma, San Diego, CA, 92130, USA.<br /><searchLink fieldCode="AU" term="%22Murphy+EA%22">Murphy EA</searchLink>; Kinnate Biopharma, San Diego, CA, 92130, USA.<br /><searchLink fieldCode="AU" term="%22Khanna+V%22">Khanna V</searchLink>; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Neal+JW%22">Neal JW</searchLink>; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Chen+CT%22">Chen CT</searchLink>; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.<br /><searchLink fieldCode="AU" term="%22Kato+S%22">Kato S</searchLink>; Division of Hematology and Oncology, University of California San Diego, Moores Cancer Center, La Jolla, CA, 92093, USA.<br /><searchLink fieldCode="AU" term="%22Williams+R%22">Williams R</searchLink>; Kinnate Biopharma, San Diego, CA, 92130, USA.<br /><searchLink fieldCode="AU" term="%22Bivona+TG%22">Bivona TG</searchLink>; Department of Medicine, University of California, San Francisco, San Francisco, CA, 94158, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, 94158, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, CA 94158, USA.
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