Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders.
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| Title: | Rare coding mutations identify 36 large-effect risk genes in obsessive-compulsive disorder and chronic tic disorders. |
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| Authors: | Wang B; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Tran MN; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Wang S; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Liu Y; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA., Olfson E; Child Study Center, Yale School of Medicine, New Haven, CT, USA., Wang G; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Sun N; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Dea J; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Olwal CO; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA., Bertolace L; Department of Psychiatry, University of Rochester, Rochester, NY, USA., Bloch MH; Child Study Center, Yale School of Medicine, New Haven, CT, USA., Cappi C; Department of Psychiatry, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Chang YC; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Chavira D; Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA., Coffey BJ; Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA., Falkenstein MJ; OCD Institute, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Frank AC; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Franklin ME; Rogers Behavioral Health, Philadelphia, PA, USA., Garayalde S; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Garrido H; Private practice, San José, Costa Rica., Grados M; Department of Psychiatry and Behavioral Sciences, Child and Adolescent Psychiatry, Johns Hopkins University, Baltimore, MD, USA., Hatem R; Department of Psychiatry and Human Behavior, Thomas Jefferson University Hospital, Philadelphia, PA, USA., Howell AL; OCD Institute, McLean Hospital, Belmont, MA, USA., Khim S; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Kuckertz JM; OCD Institute, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Le MM; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Libby A; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., McCarty RJ; Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA., McNamara ME; OCD Institute, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., McNeil D; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Miguel EC; Departamento de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Nasello C; Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Nguyen B; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Norbu T; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Oh L; OCD Institute, McLean Hospital, Belmont, MA, USA., Ordway A; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Paciotti C; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Peskin VA; Asociación de Psiquiatras de Argentina, Buenos Aires, Argentina., Pittenger C; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Department of Psychology, Yale University Graduate School of Arts and Sciences, New Haven, CT, USA.; Child Study Center, Yale School of Medicine, New Haven, CT, USA.; Center for Brain and Mind Health, Yale School of Medicine, New Haven, CT, USA.; Wu-Tsai Institute, Yale University, New Haven, CT, USA., Simpson HB; Department of Psychiatry, Columbia University, New York, NY, USA.; Center for OCD and Related Disorders, New York State Psychiatric Institute, New York, NY, USA., Martin HS; UF Health Rehab Center, Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA., Tischfield MA; Department of Cell Biology and Neuroscience, Rutgers, the State University of New Jersey, Piscataway, NJ, USA.; Child Health Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA., Xing J; Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Zakrzewski JJ; Department of Psychiatry, University of California, San Diego, San Diego, CA, USA., Dietrich A; Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Accare Child Study Center, Groningen, The Netherlands.; The Research School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands., Gilbert DL; Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Hoekstra PJ; Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Accare Child Study Center, Groningen, The Netherlands.; The Research School of Behavioral and Cognitive Neurosciences, University of Groningen, Groningen, The Netherlands., Kim YS; Department of Psychiatry and Behavioral Sciences, Dell Medical School, University of Texas at Austin, Austin, TX, USA., Kuperman S; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA., Rosen A; Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Zinner SH; Department of Pediatrics, Division of Developmental Medicine, University of Washington School of Medicine, Seattle, WA, USA., Bouhaddou M; Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, CA, USA., King RA; Child Study Center, Yale School of Medicine, New Haven, CT, USA., Rouleau G; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada., Ressler KJ; OCD Institute, McLean Hospital, Belmont, MA, USA.; Department of Psychiatry, Harvard Medical School, Boston, MA, USA., Mathews CA; Department of Psychiatry, University of Florida, Gainesville, FL, USA.; Genetics Institute, University of Florida, Gainesville, FL, USA.; Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL, USA.; Center for OCD, Anxiety and Related Disorders, University of Florida, Gainesville, FL, USA., Krogan NJ; Quantitative Biosciences Institute (QBI), University of California San Francisco, San Francisco, CA, USA.; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.; Gladstone Institute of Data Science and Biotechnology, J. David Gladstone Institutes, San Francisco, CA, USA., Sestan N; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA., Tischfield JA; Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Lee AM; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., Heiman GA; Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway, NJ, USA., Fernandez TV; Child Study Center, Yale School of Medicine, New Haven, CT, USA.; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA., Willsey AJ; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA., State MW; Department of Psychiatry and Behavioral Sciences, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA. |
| Corporate Authors: | Tourette International Collaborative Genetics (TIC Genetics) |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2025 Oct 14. Date of Electronic Publication: 2025 Oct 14. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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