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Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil.

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Title: Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil.
Authors: Mendelsohn SC; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Andrade BB; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil., Araújo-Pereira M; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil., Amorim GC; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Erasmus M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Andrade AM; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil., Fisher M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Figueiredo MC; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Muwanga VM; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Kritski AL; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, 255, Centro de Pesquisa em Tuberculose, Cidade Universitária, 21941-913, Rio de Janeiro, RJ, Brazil., Cordeiro-Santos M; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas 69040-000, Brazil., Rolla VC; Laboratorio de Pesquisa Clinica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-360, Brazil., Hatherill M; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa., Sterling TR; Vanderbilt University Medical Center, Nashville, TN 37232, USA., Scriba TJ; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.
Corporate Authors: members of the RePORT South Africa, RePORT-Brazil Consortia
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Oct 08. Date of Electronic Publication: 2025 Oct 08.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Blood transcriptomic signatures predict poor treatment outcomes in drug-susceptible pulmonary TB in Brazil.
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  Data: <searchLink fieldCode="AU" term="%22Mendelsohn+SC%22">Mendelsohn SC</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Andrade+BB%22">Andrade BB</searchLink>; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil.<br /><searchLink fieldCode="AU" term="%22Araújo-Pereira+M%22">Araújo-Pereira M</searchLink>; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil.<br /><searchLink fieldCode="AU" term="%22Amorim+GC%22">Amorim GC</searchLink>; Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Erasmus+M%22">Erasmus M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Andrade+AM%22">Andrade AM</searchLink>; Laboratório de Pesquisa Clínica e Translacional, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia 40296-710, Brazil.<br /><searchLink fieldCode="AU" term="%22Fisher+M%22">Fisher M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Figueiredo+MC%22">Figueiredo MC</searchLink>; Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Muwanga+VM%22">Muwanga VM</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Kritski+AL%22">Kritski AL</searchLink>; Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Prof Rodolpho Paulo Rocco, 255, Centro de Pesquisa em Tuberculose, Cidade Universitária, 21941-913, Rio de Janeiro, RJ, Brazil.<br /><searchLink fieldCode="AU" term="%22Cordeiro-Santos+M%22">Cordeiro-Santos M</searchLink>; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas 69040-000, Brazil.<br /><searchLink fieldCode="AU" term="%22Rolla+VC%22">Rolla VC</searchLink>; Laboratorio de Pesquisa Clinica em Micobacterioses, Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-360, Brazil.<br /><searchLink fieldCode="AU" term="%22Hatherill+M%22">Hatherill M</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.<br /><searchLink fieldCode="AU" term="%22Sterling+TR%22">Sterling TR</searchLink>; Vanderbilt University Medical Center, Nashville, TN 37232, USA.<br /><searchLink fieldCode="AU" term="%22Scriba+TJ%22">Scriba TJ</searchLink>; South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine and Division of Immunology, Department of Pathology, University of Cape Town, Anzio Road, Observatory, 7935, Cape Town, South Africa.
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  Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2025 Oct 08. <i>Date of Electronic Publication: </i>2025 Oct 08.
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        Value: 10.1101/2025.10.07.25337480
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      – Code: eng
        Text: English
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