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Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia.

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Title: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia.
Authors: Guggilla V; Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, 625 N Michigan Ave, 15th Floor, Chicago, Illinois 60611, USA., Pickens CO; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Donnelly HK; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Pawlowski A; Northwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine, 420 E Superior St, Chicago, Illinois 60611, USA., Korth E; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Martinez F; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Clepp RK; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Budinger GS; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA., Misharin AV; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA., Nadig NR; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Singer BD; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA., Gao CA; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA., Walunas TL; Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, 625 N Michigan Ave, 15th Floor, Chicago, Illinois 60611, USA.; Division of General Internal Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Dr, 10th Floor, Chicago, Illinois 60611, USA., Wunderink RG; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA.
Corporate Authors: NU SCRIPT Study Investigators
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2025 Nov 06. Date of Electronic Publication: 2025 Nov 06.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Microbial cell-free DNA sequencing of bronchoalveolar lavage fluid improves diagnostic yield and may add clinical utility in immunocompromised patients with severe pneumonia.
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  Data: <searchLink fieldCode="AU" term="%22Guggilla+V%22">Guggilla V</searchLink>; Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, 625 N Michigan Ave, 15th Floor, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Pickens+CO%22">Pickens CO</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Donnelly+HK%22">Donnelly HK</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Pawlowski+A%22">Pawlowski A</searchLink>; Northwestern Medicine Enterprise Data Warehouse, Northwestern University Feinberg School of Medicine, 420 E Superior St, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Korth+E%22">Korth E</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Martinez+F%22">Martinez F</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Clepp+RK%22">Clepp RK</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Budinger+GS%22">Budinger GS</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Misharin+AV%22">Misharin AV</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Nadig+NR%22">Nadig NR</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Singer+BD%22">Singer BD</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Gao+CA%22">Gao CA</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Walunas+TL%22">Walunas TL</searchLink>; Institute for Artificial Intelligence in Medicine, Northwestern University Feinberg School of Medicine, 625 N Michigan Ave, 15th Floor, Chicago, Illinois 60611, USA.; Division of General Internal Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Dr, 10th Floor, Chicago, Illinois 60611, USA.<br /><searchLink fieldCode="AU" term="%22Wunderink+RG%22">Wunderink RG</searchLink>; Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Suite 2330, Chicago, Illinois 60611, USA.; Simpson Querrey Lung Institute for Translational Science, Northwestern University Feinberg School of Medicine, 303 E Superior St, SQBMRC 5th Floor, Chicago, Illinois 60611, USA.
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PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41282925
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        Value: 10.1101/2025.11.05.25339543
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      – Code: eng
        Text: English
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              Text: 2025 Nov 06
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