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A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling.

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Title: A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling.
Authors: Rahimov F; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA. fedik.rahimov@abbvie.com., Ghosh S; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Petiwala S; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Schmidt M; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Nyamugenda E; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Shi M; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Tam J; Immunology Discovery Research, AbbVie Inc., Cambridge, MA, USA., Verduzco D; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Singh S; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Avram V; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA., Modi A; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Espinoza CA; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Lu C; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Wang J; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA., Keller A; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Macoritto M; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA., Mahi NA; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA., Anton T; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Chung N; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Flister MJ; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Katlinski KV; Immunology Discovery Research, AbbVie Inc., Cambridge, MA, USA., Biswas A; Immunology Discovery Research, AbbVie Inc., Cambridge, MA, USA., den Hollander AI; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Waring JF; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA., Stender JD; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA. joshua.stender@abbvie.com.
Source: Nature communications [Nat Commun] 2025 Nov 24; Vol. 16 (1), pp. 10346. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A genome-wide CRISPR screen identifies the TNRC18 gene locus as a regulator of inflammatory signaling.
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  Data: <searchLink fieldCode="AU" term="%22Rahimov+F%22">Rahimov F</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA. fedik.rahimov@abbvie.com.<br /><searchLink fieldCode="AU" term="%22Ghosh+S%22">Ghosh S</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Petiwala+S%22">Petiwala S</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Schmidt+M%22">Schmidt M</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Nyamugenda+E%22">Nyamugenda E</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Shi+M%22">Shi M</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Tam+J%22">Tam J</searchLink>; Immunology Discovery Research, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Verduzco+D%22">Verduzco D</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Avram+V%22">Avram V</searchLink>; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Modi+A%22">Modi A</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Espinoza+CA%22">Espinoza CA</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Lu+C%22">Lu C</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Keller+A%22">Keller A</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Macoritto+M%22">Macoritto M</searchLink>; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mahi+NA%22">Mahi NA</searchLink>; Genomics Research Center, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Anton+T%22">Anton T</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Chung+N%22">Chung N</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Flister+MJ%22">Flister MJ</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Katlinski+KV%22">Katlinski KV</searchLink>; Immunology Discovery Research, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Biswas+A%22">Biswas A</searchLink>; Immunology Discovery Research, AbbVie Inc., Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22den+Hollander+AI%22">den Hollander AI</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Waring+JF%22">Waring JF</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA.<br /><searchLink fieldCode="AU" term="%22Stender+JD%22">Stender JD</searchLink>; Genomics Research Center, AbbVie Inc., North Chicago, IL, USA. joshua.stender@abbvie.com.
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