The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis.
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| Title: | The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis. |
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| Authors: | Sillassen CDB; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark. christina.sillassen@ctu.dk.; Department of Cardiology and Endocrinology, Slagelse Hospital, Slagelse, Region of Zealand, Denmark. christina.sillassen@ctu.dk.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. christina.sillassen@ctu.dk., Petersen JJ; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark., Faltermeier P; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Yucel D; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark., Siddiqui F; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark., Andersen RK; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark., Graever L; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Bjerg JL; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark., Kamp CB; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark., Grand J; Department of Cardiology, Copenhagen University Hospital - Amager-Hvidovre Hospital, Copenhagen, Denmark., Dominguez H; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark., Frølich A; Innovation and Research Centre for Multimorbidity, Slagelse Hospital, Slagelse, Region of Zealand, Denmark.; Section of General Practice, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Gæde P; Department of Cardiology and Endocrinology, Slagelse Hospital, Slagelse, Region of Zealand, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Gluud C; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Mathiesen O; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark., Jakobsen JC; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. |
| Source: | BMC medicine [BMC Med] 2025 Nov 24; Vol. 23 (1), pp. 654. Date of Electronic Publication: 2025 Nov 24. |
| Publication Type: | Journal Article; Systematic Review; Meta-Analysis |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41286875 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Sillassen+CDB%22">Sillassen CDB</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark. christina.sillassen@ctu.dk.; Department of Cardiology and Endocrinology, Slagelse Hospital, Slagelse, Region of Zealand, Denmark. christina.sillassen@ctu.dk.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. christina.sillassen@ctu.dk.<br /><searchLink fieldCode="AU" term="%22Petersen+JJ%22">Petersen JJ</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Faltermeier+P%22">Faltermeier P</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Yucel+D%22">Yucel D</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Siddiqui+F%22">Siddiqui F</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+RK%22">Andersen RK</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Graever+L%22">Graever L</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.<br /><searchLink fieldCode="AU" term="%22Bjerg+JL%22">Bjerg JL</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Kamp+CB%22">Kamp CB</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Grand+J%22">Grand J</searchLink>; Department of Cardiology, Copenhagen University Hospital - Amager-Hvidovre Hospital, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Dominguez+H%22">Dominguez H</searchLink>; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital - Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Frølich+A%22">Frølich A</searchLink>; Innovation and Research Centre for Multimorbidity, Slagelse Hospital, Slagelse, Region of Zealand, Denmark.; Section of General Practice, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Gæde+P%22">Gæde P</searchLink>; Department of Cardiology and Endocrinology, Slagelse Hospital, Slagelse, Region of Zealand, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Gluud+C%22">Gluud C</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Mathiesen+O%22">Mathiesen O</searchLink>; Department of Anaesthesiology, Centre for Anaesthesiological Research, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jakobsen+JC%22">Jakobsen JC</searchLink>; Copenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital -Rigshospitalet, The Capital Region, Copenhagen, Denmark.; Department of Regional Health Research, The Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2025 Nov 24; Vol. 23 (1), pp. 654. <i>Date of Electronic Publication: </i>2025 Nov 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Systematic Review; Meta-Analysis – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190723 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1741-7015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217417015%22">17417015 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41286875 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12916-025-04486-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 654 Titles: – TitleFull: The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sillassen CDB – PersonEntity: Name: NameFull: Petersen JJ – PersonEntity: Name: NameFull: Faltermeier P – PersonEntity: Name: NameFull: Yucel D – PersonEntity: Name: NameFull: Siddiqui F – PersonEntity: Name: NameFull: Andersen RK – PersonEntity: Name: NameFull: Graever L – PersonEntity: Name: NameFull: Bjerg JL – PersonEntity: Name: NameFull: Kamp CB – PersonEntity: Name: NameFull: Grand J – PersonEntity: Name: NameFull: Dominguez H – PersonEntity: Name: NameFull: Frølich A – PersonEntity: Name: NameFull: Gæde P – PersonEntity: Name: NameFull: Gluud C – PersonEntity: Name: NameFull: Mathiesen O – PersonEntity: Name: NameFull: Jakobsen JC IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 11 Text: 2025 Nov 24 Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1741-7015 Numbering: – Type: volume Value: 23 – Type: issue Value: 1 Titles: – TitleFull: BMC medicine Type: main |
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