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Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action.

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Title: Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action.
Authors: Dakroub F; Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon; Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon., Awada B; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida., Abdelhady S; Faculty of Medicine, Alexandria University, Alexandria, Egypt., Shaito AA; Biomedical Research Center (BRC) and Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Qatar; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Qatar., Eid AH; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Qatar., Walker J; Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology and Neuroscience Institute, Morehouse School of Medicine (MSM), Atlanta, Georgia., Mondello S; Biomedical and Dental Sciences and Morphofunctional Imaging, Faculty of Medicine and Surgery, University of Messina, Messina, Italy., Bondi CO; Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania., Moro F; Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy., Elgendy B; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences & Pharmacy, St. Louis, Missouri., Wang KK; Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology and Neuroscience Institute, Morehouse School of Medicine (MSM), Atlanta, Georgia., Zanier ER; Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy. Electronic address: elisa.zanier@marionegri.it., Mechref Y; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Electronic address: yehia.mechref@ttu.edu., Kobeissy F; Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology and Neuroscience Institute, Morehouse School of Medicine (MSM), Atlanta, Georgia. Electronic address: firasko@gmail.com.
Source: Pharmacological reviews [Pharmacol Rev] 2026 Jan; Vol. 78 (1), pp. 100101. Date of Electronic Publication: 2025 Oct 26.
Publication Type: Journal Article; Review
Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0421737 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0081 (Electronic) Linking ISSN: 00316997 NLM ISO Abbreviation: Pharmacol Rev Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Edaravone: Advances on cytoprotective effects, pharmacological properties, and mechanisms of action.
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  Data: <searchLink fieldCode="AU" term="%22Dakroub+F%22">Dakroub F</searchLink>; Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon; Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.<br /><searchLink fieldCode="AU" term="%22Awada+B%22">Awada B</searchLink>; The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida.<br /><searchLink fieldCode="AU" term="%22Abdelhady+S%22">Abdelhady S</searchLink>; Faculty of Medicine, Alexandria University, Alexandria, Egypt.<br /><searchLink fieldCode="AU" term="%22Shaito+AA%22">Shaito AA</searchLink>; Biomedical Research Center (BRC) and Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Qatar; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Qatar.<br /><searchLink fieldCode="AU" term="%22Eid+AH%22">Eid AH</searchLink>; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Qatar.<br /><searchLink fieldCode="AU" term="%22Walker+J%22">Walker J</searchLink>; Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology and Neuroscience Institute, Morehouse School of Medicine (MSM), Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Mondello+S%22">Mondello S</searchLink>; Biomedical and Dental Sciences and Morphofunctional Imaging, Faculty of Medicine and Surgery, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Bondi+CO%22">Bondi CO</searchLink>; Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania; Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania.<br /><searchLink fieldCode="AU" term="%22Moro+F%22">Moro F</searchLink>; Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.<br /><searchLink fieldCode="AU" term="%22Elgendy+B%22">Elgendy B</searchLink>; Department of Anesthesiology, Washington University in St. Louis, St. Louis, Missouri; Center for Clinical Pharmacology, Washington University School of Medicine and University of Health Sciences & Pharmacy, St. Louis, Missouri.<br /><searchLink fieldCode="AU" term="%22Wang+KK%22">Wang KK</searchLink>; Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology and Neuroscience Institute, Morehouse School of Medicine (MSM), Atlanta, Georgia.<br /><searchLink fieldCode="AU" term="%22Zanier+ER%22">Zanier ER</searchLink>; Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy. Electronic address: elisa.zanier@marionegri.it.<br /><searchLink fieldCode="AU" term="%22Mechref+Y%22">Mechref Y</searchLink>; Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas. Electronic address: yehia.mechref@ttu.edu.<br /><searchLink fieldCode="AU" term="%22Kobeissy+F%22">Kobeissy F</searchLink>; Center for Neurotrauma, Multiomics & Biomarkers, Department of Neurobiology and Neuroscience Institute, Morehouse School of Medicine (MSM), Atlanta, Georgia. Electronic address: firasko@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%220421737%22">Pharmacological reviews</searchLink> [Pharmacol Rev] 2026 Jan; Vol. 78 (1), pp. 100101. <i>Date of Electronic Publication: </i>2025 Oct 26.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Society+for+Pharmacology+and+Experimental+Therapeutics%22">American Society for Pharmacology and Experimental Therapeutics </searchLink><i>Country of Publication: </i>Netherlands <i>NLM ID: </i>0421737 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1521-0081 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200316997%22">00316997 </searchLink><i>NLM ISO Abbreviation: </i>Pharmacol Rev <i>Subsets: </i>MEDLINE
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              Text: 2026 Jan
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