Intraperitoneal infusion of stem cell-derived natural killer cells in recurrent epithelial ovarian cancer patients: Results of the phase 1 INTRO-01 trial.
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| Title: | Intraperitoneal infusion of stem cell-derived natural killer cells in recurrent epithelial ovarian cancer patients: Results of the phase 1 INTRO-01 trial. |
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| Authors: | Hoogstad-van Evert JS; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands; Department of Gynecology, Amphia hospital, Breda, the Netherlands., de Jonge PKJD; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Zusterzeel PLM; Department of Gynecology, Radboud university medical center, Nijmegen, the Netherlands., Hobo W; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., van der Waart AB; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Fredrix H; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Janssen L; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Wuts M; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Bosmans L; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Spijkers E; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Djojoatmo M; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Rodriguez VC; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., de Goede AL; Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, the Netherlands., van der Reijden B; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., van der Meer A; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud university medical center, Nijmegen, the Netherlands., Schaap N; Department of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Bekkers R; Department of Gynecology, Radboud university medical center, Nijmegen, the Netherlands; Department of Obstetrics and Gynecology, Catharina Hospital Eindhoven, the Netherlands; GROW school for oncology and reproduction, Maastricht University, Maastricht, the Netherlands., Jansen JH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands., Ottevanger N; Department of Medical Oncology, Radboud university medical center, Nijmegen, the Netherlands., Dolstra H; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands. Electronic address: harry.dolstra@radboudumc.nl. |
| Source: | Gynecologic oncology [Gynecol Oncol] 2026 Jan; Vol. 204, pp. 91-99. Date of Electronic Publication: 2025 Nov 24. |
| Publication Type: | Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Academic Press Country of Publication: United States NLM ID: 0365304 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6859 (Electronic) Linking ISSN: 00908258 NLM ISO Abbreviation: Gynecol Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41289795 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Intraperitoneal infusion of stem cell-derived natural killer cells in recurrent epithelial ovarian cancer patients: Results of the phase 1 INTRO-01 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Hoogstad-van+Evert+JS%22">Hoogstad-van Evert JS</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands; Department of Gynecology, Amphia hospital, Breda, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Jonge+PKJD%22">de Jonge PKJD</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zusterzeel+PLM%22">Zusterzeel PLM</searchLink>; Department of Gynecology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hobo+W%22">Hobo W</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Waart+AB%22">van der Waart AB</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Fredrix+H%22">Fredrix H</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Janssen+L%22">Janssen L</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wuts+M%22">Wuts M</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bosmans+L%22">Bosmans L</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Spijkers+E%22">Spijkers E</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Djojoatmo+M%22">Djojoatmo M</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rodriguez+VC%22">Rodriguez VC</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Goede+AL%22">de Goede AL</searchLink>; Department of Pharmacy, Pharmacology and Toxicology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Reijden+B%22">van der Reijden B</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Meer+A%22">van der Meer A</searchLink>; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Schaap+N%22">Schaap N</searchLink>; Department of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Bekkers+R%22">Bekkers R</searchLink>; Department of Gynecology, Radboud university medical center, Nijmegen, the Netherlands; Department of Obstetrics and Gynecology, Catharina Hospital Eindhoven, the Netherlands; GROW school for oncology and reproduction, Maastricht University, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Jansen+JH%22">Jansen JH</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Ottevanger+N%22">Ottevanger N</searchLink>; Department of Medical Oncology, Radboud university medical center, Nijmegen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Dolstra+H%22">Dolstra H</searchLink>; Department of Laboratory Medicine, Laboratory of Hematology, Radboud university medical center, Nijmegen, the Netherlands. Electronic address: harry.dolstra@radboudumc.nl. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220365304%22">Gynecologic oncology</searchLink> [Gynecol Oncol] 2026 Jan; Vol. 204, pp. 91-99. <i>Date of Electronic Publication: </i>2025 Nov 24. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Academic+Press%22">Academic Press </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0365304 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-6859 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200908258%22">00908258 </searchLink><i>NLM ISO Abbreviation: </i>Gynecol Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41289795 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.ygyno.2025.11.006 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 91 Titles: – TitleFull: Intraperitoneal infusion of stem cell-derived natural killer cells in recurrent epithelial ovarian cancer patients: Results of the phase 1 INTRO-01 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hoogstad-van Evert JS – PersonEntity: Name: NameFull: de Jonge PKJD – PersonEntity: Name: NameFull: Zusterzeel PLM – PersonEntity: Name: NameFull: Hobo W – PersonEntity: Name: NameFull: van der Waart AB – PersonEntity: Name: NameFull: Fredrix H – PersonEntity: Name: NameFull: Janssen L – PersonEntity: Name: NameFull: Wuts M – PersonEntity: Name: NameFull: Bosmans L – PersonEntity: Name: NameFull: Spijkers E – PersonEntity: Name: NameFull: Djojoatmo M – PersonEntity: Name: NameFull: Rodriguez VC – PersonEntity: Name: NameFull: de Goede AL – PersonEntity: Name: NameFull: van der Reijden B – PersonEntity: Name: NameFull: van der Meer A – PersonEntity: Name: NameFull: Schaap N – PersonEntity: Name: NameFull: Bekkers R – PersonEntity: Name: NameFull: Jansen JH – PersonEntity: Name: NameFull: Ottevanger N – PersonEntity: Name: NameFull: Dolstra H IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1095-6859 Numbering: – Type: volume Value: 204 Titles: – TitleFull: Gynecologic oncology Type: main |
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