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Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer.

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Title: Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer.
Authors: Almadani SA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia., Ali MAM; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia., Soliman MA; Deanship of Preparatory Year, Prince Sattam Bin Abdulaziz University, Al-Kharj 16273, Saudi Arabia., Abdur-Rahman M; Chemistry Department, Faculty of Science, Cairo University, Cairo 12613, Egypt., Bendif H; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia., Elfalleh W; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia., Samman WA; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia; Health and Life Research Center, Taibah University, Madinah 42353, Saudi Arabia., Alghamdi R; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia., Aouad MR; Department of Chemistry, College of Sciences, Taibah University, Madinah 30002, Saudi Arabia., Zaki MEA; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia., Gomha SM; Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia., Ahmed HEA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt. Electronic address: heahmad@azhar.edu.eg.
Source: Bioorganic chemistry [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109288. Date of Electronic Publication: 2025 Nov 22.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Nanogel delivered benzimidazole-triazole hybrids as potent multitarget inhibitors of topoisomerase and tubulin in triple-negative breast cancer.
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  Data: <searchLink fieldCode="AU" term="%22Almadani+SA%22">Almadani SA</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ali+MAM%22">Ali MAM</searchLink>; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Soliman+MA%22">Soliman MA</searchLink>; Deanship of Preparatory Year, Prince Sattam Bin Abdulaziz University, Al-Kharj 16273, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Abdur-Rahman+M%22">Abdur-Rahman M</searchLink>; Chemistry Department, Faculty of Science, Cairo University, Cairo 12613, Egypt.<br /><searchLink fieldCode="AU" term="%22Bendif+H%22">Bendif H</searchLink>; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Elfalleh+W%22">Elfalleh W</searchLink>; Department of Biology, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Samman+WA%22">Samman WA</searchLink>; Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia; Health and Life Research Center, Taibah University, Madinah 42353, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Alghamdi+R%22">Alghamdi R</searchLink>; Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Madinah 42353, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Aouad+MR%22">Aouad MR</searchLink>; Department of Chemistry, College of Sciences, Taibah University, Madinah 30002, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Zaki+MEA%22">Zaki MEA</searchLink>; Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Gomha+SM%22">Gomha SM</searchLink>; Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Ahmed+HEA%22">Ahmed HEA</searchLink>; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt. Electronic address: heahmad@azhar.edu.eg.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2025 Dec; Vol. 167, pp. 109288. <i>Date of Electronic Publication: </i>2025 Nov 22.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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