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LIVERATION trial: a multicentre European randomised study on radiofrequency margin coagulation and its impact on oncological outcomes after liver surgery - study protocol.

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Title: LIVERATION trial: a multicentre European randomised study on radiofrequency margin coagulation and its impact on oncological outcomes after liver surgery - study protocol.
Authors: Luque Villalobos E; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain., Ielpo B; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain., Aldrighetti L; Department of HBP Surgery, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy., Anselmo A; Department of HBP Surgery, Fondazione PTV Policlinico Tor Vergata, Roma, Lazio, Italy., Beghdadi N; Department of HBP Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, Île-de-France, France., Berardi G; Department of HBP Surgery, San Camillo Forlanini Hospital, Roma, Lazio, Italy., Briceño F; Department of HBP Surgery and Liver Transplantation, Hospital Universitario Reina Sofia, Córdoba, Andalucía, Spain., Ciria R; Department of HBP Surgery and Liver Transplantation, Hospital Universitario Reina Sofia, Córdoba, Andalucía, Spain., Dorcaratto D; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain., Durczynski A; Department of HBP Surgery, Norbert Barlicki Memorial University Hospital, Medical University of Lodz, Lodz, Poland., Ettorre GM; Department of HBP Surgery, San Camillo Forlanini Hospital, Roma, Lazio, Italy., Delvecchio A; Unit of Hepato-Biliary and Pancreatic Surgery, 'F. Miulli' General Hospital, 70021 Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM University, 70010 Casamassima, Bari, Italy., Ferri V; Service of General and Digestive Surgery, Sanchinarro University Hospital, Clara Campal Oncological Center, Health Sciences Faculty, HM Hospitals. Carrillo José Cela University, Madrid, Community of Madrid, Spain., Grąt M; Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland., Garces-Albir M; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain., Grochola LF; Department of HBP Surgery, Kantonsspital Winterthur, Winterthur, Zurich, Switzerland., Hogendorf P; Department of HBP Surgery, Norbert Barlicki Memorial University Hospital, Medical University of Lodz, Lodz, Poland., Izzo F; Department of HBP Surgery, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Campania, Italy., Kobryn K; Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland., Kontis E; Department of HBP Surgery, Metaxa Cancer Hospital of Piraeus, Piraeus, Attika, Greece., Korkolis D; Department of HBP Surgery, Agios Savvas General Cancer and Oncology Hospital of Athens, Athens, Attica, Greece., Król R; Department of HBP Surgery, Medical University of Silesia in Katowice, Department of General, Vascular and Transplant Surgery, Katowice, Silesian Voivodeship, Poland., Lesurtel M; Department of HBP Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, Île-de-France, France., Lopez-Ben S; Department of HBP Surgery, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Catalunya, Spain., Christogiannis C; Department of Primary Education, University of Ioannina, Ioannina, Greece., Koutsiouroumpa O; Department of Primary Education, University of Ioannina, Ioannina, Greece., Mavridis D; Department of Primary Education, University of Ioannina, Ioannina, Greece., Memeo R; Unit of Hepato-Biliary and Pancreatic Surgery, 'F. Miulli' General Hospital, 70021 Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM University, 70010 Casamassima, Bari, Italy., Murawa D; Department of General Surgery and Surgical Oncology; Chair of Surgical Oncology, The Regional Hospital in Poznan -The Greater Poland Specialist Center; Collegium Medicum, University of Zielona Góra, Poznań, Zielona Gora, Poland., Machairas N; Department of HBP Surgery, National and Kapodistrian University of Athens General Hospital of Athens Laiko, Athens, Attica, Greece., Mora-Oliver I; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain., Muñoz-Forner E; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain., Orrego C; Avedis Donabedian Instituto Universitario UAB, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.; Research Network on Chronicity Primary Care and Prevention and Health Promotion, Madrid, Spain., Dantas C; Shine 2Europe, Coimbra, Portugal., Fuste C; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain., García Picazo A; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain., Pessaux P; University Hospital of Strasbourg, Department of HBP Surgery, Nouvel Hopital Civil, Strasbourg, France., Pilat T; Department of General Surgery and Surgical Oncology; Chair of Surgical Oncology, The Regional Hospital in Poznan -The Greater Poland Specialist Center; Collegium Medicum, University of Zielona Góra, Poznań, Zielona Gora, Poland., Pittau G; Department of HBP Surgery, Paul Brousse Hospital, Villejuif, Île-de-France, France., Radosevic A; Department of Radiology, Hospital del Mar, Barcelona, Catalunya, Spain., Ratti F; Department of HBP Surgery, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy., Sotiropoulos G; Department of HBP Surgery, National and Kapodistrian University of Athens General Hospital of Athens Laiko, Athens, Attica, Greece., Toutouzas K; Department of HBP Surgery, General Hospital of Athens Ippokrateio, Athens, Attica, Greece., Trotovsek B; Department of Abdominal Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia., Wystrychowski W; Department of HBP Surgery, Medical University of Silesia in Katowice, Department of General, Vascular and Transplant Surgery, Katowice, Silesian Voivodeship, Poland., Zacharoulis D; Department of HBP Surgery, General University Hospital of Larissa, Larissa, Thessaly, Greece., Vicente E; Service of General and Digestive Surgery, Sanchinarro University Hospital, Clara Campal Oncological Center, Health Sciences Faculty, HM Hospitals. Carrillo José Cela University, Madrid, Community of Madrid, Spain., Burdio F; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain., Sánchez Velázquez P; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain patri_sv5@hotmail.com.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain.
Source: BMJ open [BMJ Open] 2025 Nov 24; Vol. 15 (11), pp. e100518. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101552874 Publication Model: Electronic Cited Medium: Internet ISSN: 2044-6055 (Electronic) Linking ISSN: 20446055 NLM ISO Abbreviation: BMJ Open Subsets: MEDLINE
Database: MEDLINE Ultimate
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Items – Name: Title
  Label: Title
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  Data: LIVERATION trial: a multicentre European randomised study on radiofrequency margin coagulation and its impact on oncological outcomes after liver surgery - study protocol.
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  Data: <searchLink fieldCode="AU" term="%22Luque+Villalobos+E%22">Luque Villalobos E</searchLink>; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Ielpo+B%22">Ielpo B</searchLink>; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Aldrighetti+L%22">Aldrighetti L</searchLink>; Department of HBP Surgery, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy.<br /><searchLink fieldCode="AU" term="%22Anselmo+A%22">Anselmo A</searchLink>; Department of HBP Surgery, Fondazione PTV Policlinico Tor Vergata, Roma, Lazio, Italy.<br /><searchLink fieldCode="AU" term="%22Beghdadi+N%22">Beghdadi N</searchLink>; Department of HBP Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, Île-de-France, France.<br /><searchLink fieldCode="AU" term="%22Berardi+G%22">Berardi G</searchLink>; Department of HBP Surgery, San Camillo Forlanini Hospital, Roma, Lazio, Italy.<br /><searchLink fieldCode="AU" term="%22Briceño+F%22">Briceño F</searchLink>; Department of HBP Surgery and Liver Transplantation, Hospital Universitario Reina Sofia, Córdoba, Andalucía, Spain.<br /><searchLink fieldCode="AU" term="%22Ciria+R%22">Ciria R</searchLink>; Department of HBP Surgery and Liver Transplantation, Hospital Universitario Reina Sofia, Córdoba, Andalucía, Spain.<br /><searchLink fieldCode="AU" term="%22Dorcaratto+D%22">Dorcaratto D</searchLink>; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Durczynski+A%22">Durczynski A</searchLink>; Department of HBP Surgery, Norbert Barlicki Memorial University Hospital, Medical University of Lodz, Lodz, Poland.<br /><searchLink fieldCode="AU" term="%22Ettorre+GM%22">Ettorre GM</searchLink>; Department of HBP Surgery, San Camillo Forlanini Hospital, Roma, Lazio, Italy.<br /><searchLink fieldCode="AU" term="%22Delvecchio+A%22">Delvecchio A</searchLink>; Unit of Hepato-Biliary and Pancreatic Surgery, 'F. Miulli' General Hospital, 70021 Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM University, 70010 Casamassima, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Ferri+V%22">Ferri V</searchLink>; Service of General and Digestive Surgery, Sanchinarro University Hospital, Clara Campal Oncological Center, Health Sciences Faculty, HM Hospitals. Carrillo José Cela University, Madrid, Community of Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Grąt+M%22">Grąt M</searchLink>; Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Garces-Albir+M%22">Garces-Albir M</searchLink>; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Grochola+LF%22">Grochola LF</searchLink>; Department of HBP Surgery, Kantonsspital Winterthur, Winterthur, Zurich, Switzerland.<br /><searchLink fieldCode="AU" term="%22Hogendorf+P%22">Hogendorf P</searchLink>; Department of HBP Surgery, Norbert Barlicki Memorial University Hospital, Medical University of Lodz, Lodz, Poland.<br /><searchLink fieldCode="AU" term="%22Izzo+F%22">Izzo F</searchLink>; Department of HBP Surgery, Istituto Nazionale Tumori IRCCS Fondazione Pascale, Naples, Campania, Italy.<br /><searchLink fieldCode="AU" term="%22Kobryn+K%22">Kobryn K</searchLink>; Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.<br /><searchLink fieldCode="AU" term="%22Kontis+E%22">Kontis E</searchLink>; Department of HBP Surgery, Metaxa Cancer Hospital of Piraeus, Piraeus, Attika, Greece.<br /><searchLink fieldCode="AU" term="%22Korkolis+D%22">Korkolis D</searchLink>; Department of HBP Surgery, Agios Savvas General Cancer and Oncology Hospital of Athens, Athens, Attica, Greece.<br /><searchLink fieldCode="AU" term="%22Król+R%22">Król R</searchLink>; Department of HBP Surgery, Medical University of Silesia in Katowice, Department of General, Vascular and Transplant Surgery, Katowice, Silesian Voivodeship, Poland.<br /><searchLink fieldCode="AU" term="%22Lesurtel+M%22">Lesurtel M</searchLink>; Department of HBP Surgery and Liver Transplantation, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, University of Paris Cité, Clichy, Île-de-France, France.<br /><searchLink fieldCode="AU" term="%22Lopez-Ben+S%22">Lopez-Ben S</searchLink>; Department of HBP Surgery, Hospital Universitari de Girona Doctor Josep Trueta, Girona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Christogiannis+C%22">Christogiannis C</searchLink>; Department of Primary Education, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Koutsiouroumpa+O%22">Koutsiouroumpa O</searchLink>; Department of Primary Education, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Mavridis+D%22">Mavridis D</searchLink>; Department of Primary Education, University of Ioannina, Ioannina, Greece.<br /><searchLink fieldCode="AU" term="%22Memeo+R%22">Memeo R</searchLink>; Unit of Hepato-Biliary and Pancreatic Surgery, 'F. Miulli' General Hospital, 70021 Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM University, 70010 Casamassima, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Murawa+D%22">Murawa D</searchLink>; Department of General Surgery and Surgical Oncology; Chair of Surgical Oncology, The Regional Hospital in Poznan -The Greater Poland Specialist Center; Collegium Medicum, University of Zielona Góra, Poznań, Zielona Gora, Poland.<br /><searchLink fieldCode="AU" term="%22Machairas+N%22">Machairas N</searchLink>; Department of HBP Surgery, National and Kapodistrian University of Athens General Hospital of Athens Laiko, Athens, Attica, Greece.<br /><searchLink fieldCode="AU" term="%22Mora-Oliver+I%22">Mora-Oliver I</searchLink>; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Muñoz-Forner+E%22">Muñoz-Forner E</searchLink>; Liver, Biliary and Pancreatic Unit. Department of General and Digestive Surgery, Hospital Clinico Universitario of Valencia. Department of Surgery. University of Valencia. Biomedical Research Institute, INCLIVA, Valencia, Spain.<br /><searchLink fieldCode="AU" term="%22Orrego+C%22">Orrego C</searchLink>; Avedis Donabedian Instituto Universitario UAB, Barcelona, Spain.; Universitat Autònoma de Barcelona, Barcelona, Spain.; Research Network on Chronicity Primary Care and Prevention and Health Promotion, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Dantas+C%22">Dantas C</searchLink>; Shine 2Europe, Coimbra, Portugal.<br /><searchLink fieldCode="AU" term="%22Fuste+C%22">Fuste C</searchLink>; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22García+Picazo+A%22">García Picazo A</searchLink>; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Pessaux+P%22">Pessaux P</searchLink>; University Hospital of Strasbourg, Department of HBP Surgery, Nouvel Hopital Civil, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Pilat+T%22">Pilat T</searchLink>; Department of General Surgery and Surgical Oncology; Chair of Surgical Oncology, The Regional Hospital in Poznan -The Greater Poland Specialist Center; Collegium Medicum, University of Zielona Góra, Poznań, Zielona Gora, Poland.<br /><searchLink fieldCode="AU" term="%22Pittau+G%22">Pittau G</searchLink>; Department of HBP Surgery, Paul Brousse Hospital, Villejuif, Île-de-France, France.<br /><searchLink fieldCode="AU" term="%22Radosevic+A%22">Radosevic A</searchLink>; Department of Radiology, Hospital del Mar, Barcelona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Ratti+F%22">Ratti F</searchLink>; Department of HBP Surgery, IRCCS Ospedale San Raffaele, Milan, Lombardy, Italy.<br /><searchLink fieldCode="AU" term="%22Sotiropoulos+G%22">Sotiropoulos G</searchLink>; Department of HBP Surgery, National and Kapodistrian University of Athens General Hospital of Athens Laiko, Athens, Attica, Greece.<br /><searchLink fieldCode="AU" term="%22Toutouzas+K%22">Toutouzas K</searchLink>; Department of HBP Surgery, General Hospital of Athens Ippokrateio, Athens, Attica, Greece.<br /><searchLink fieldCode="AU" term="%22Trotovsek+B%22">Trotovsek B</searchLink>; Department of Abdominal Surgery, University Medical Centre Ljubljana, Ljubljana, Slovenia.<br /><searchLink fieldCode="AU" term="%22Wystrychowski+W%22">Wystrychowski W</searchLink>; Department of HBP Surgery, Medical University of Silesia in Katowice, Department of General, Vascular and Transplant Surgery, Katowice, Silesian Voivodeship, Poland.<br /><searchLink fieldCode="AU" term="%22Zacharoulis+D%22">Zacharoulis D</searchLink>; Department of HBP Surgery, General University Hospital of Larissa, Larissa, Thessaly, Greece.<br /><searchLink fieldCode="AU" term="%22Vicente+E%22">Vicente E</searchLink>; Service of General and Digestive Surgery, Sanchinarro University Hospital, Clara Campal Oncological Center, Health Sciences Faculty, HM Hospitals. Carrillo José Cela University, Madrid, Community of Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Burdio+F%22">Burdio F</searchLink>; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain.<br /><searchLink fieldCode="AU" term="%22Sánchez+Velázquez+P%22">Sánchez Velázquez P</searchLink>; Department of HBP Surgery, Hospital del Mar, Barcelona, Catalunya, Spain patri_sv5@hotmail.com.; Hospital del Mar Research Institute IMIM, Barcelona, Catalunya, Spain.; Universitat Pompeu Fabra, Barcelona, Catalunya, Spain.
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  Data: <searchLink fieldCode="JN" term="%22101552874%22">BMJ open</searchLink> [BMJ Open] 2025 Nov 24; Vol. 15 (11), pp. e100518. <i>Date of Electronic Publication: </i>2025 Nov 24.
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  Data: Journal Article; Clinical Trial Protocol
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      – PersonEntity:
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            NameFull: Toutouzas K
      – PersonEntity:
          Name:
            NameFull: Trotovsek B
      – PersonEntity:
          Name:
            NameFull: Wystrychowski W
      – PersonEntity:
          Name:
            NameFull: Zacharoulis D
      – PersonEntity:
          Name:
            NameFull: Vicente E
      – PersonEntity:
          Name:
            NameFull: Burdio F
      – PersonEntity:
          Name:
            NameFull: Sánchez Velázquez P
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 24
              M: 11
              Text: 2025 Nov 24
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-electronic
              Value: 2044-6055
          Numbering:
            – Type: volume
              Value: 15
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: BMJ open
              Type: main
ResultId 1