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MAO-B status in alcohol use disorder: a [11C]SL25.1188 PET imaging study of putative astrogliosis.

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Title: MAO-B status in alcohol use disorder: a [11C]SL25.1188 PET imaging study of putative astrogliosis.
Authors: Best LM; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada., Truong J; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada., McCluskey T; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada., Meyer JH; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5G 2C8, ON, Canada., Rusjan P; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; The Douglas Research Centre, McGill University, Montreal, H4H 1R3, QC, Canada., Dheda SS; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada., Pandian J; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada., Tardelli VS; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Centro de Estudos Psiquiátricos Américo Bairral, 13970-450, Itapira, SP, Brazil.; Addictions Division, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada., Rubin-Kahana DS; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; McCain Centre for Child, Youth and Family Mental Health, Centre for Addiction and Mental Health, Toronto, ON, Canada, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada., Rhind SG; Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, M5S 3J7, ON, Canada.; Defence Research and Development Canada, Toronto Research Centre, Toronto, M3K 2C9, ON, Canada., Le Foll B; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5G 2C8, ON, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Family and Community Medicine, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Waypoint Research Institute, Waypoint Centre for Mental Health Care, Penetanguishene, L9M 1G3, ON, Canada., Warsh J; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5G 2C8, ON, Canada., Kish SJ; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5G 2C8, ON, Canada., Boileau I; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada. isabelle.boileau@camh.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5G 2C8, ON, Canada. isabelle.boileau@camh.ca.; Addictions Division, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada. isabelle.boileau@camh.ca.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Apr; Vol. 31 (4), pp. 2191-2201. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
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  Data: MAO-B status in alcohol use disorder: a [<superscript>11</superscript>C]SL25.1188 PET imaging study of putative astrogliosis.
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Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Psychiatry, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, M5G 2C8, ON, Canada.; Addictions Division, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; Department of Family and Community Medicine, University of Toronto, Toronto, M5T 1R8, ON, Canada.; Waypoint Research Institute, Waypoint Centre for Mental Health Care, Penetanguishene, L9M 1G3, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Warsh+J%22">Warsh J</searchLink>; Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, M5T 1R8, ON, Canada.; Institute of Medical Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, M5S 3H2, ON, Canada.; Campbell Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada.; 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Addictions Division, Centre for Addiction and Mental Health, Toronto, M6J 1H4, ON, Canada. isabelle.boileau@camh.ca.
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