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Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.

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Title: Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.
Authors: Eskiocak O; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA., Gewolb J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Shah V; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Rutgers New Jersey Medical School, Newark, NJ, USA., Rouse JA; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Chowdhury S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Akyildiz EO; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Molecular and Translational Biomedicine Program, Institute of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey., Fernández-Maestre I; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Boyer JA; Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, USA.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA., Filliol A; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Harris AS; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Utama R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Guo G; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Castro-Hernández C; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Nnuji-John E; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Chung C; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA., Anderson A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Flowers S; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Habel J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Romesser PB; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA., Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Lowe SW; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sadelain M; Columbia Initiative in Cell Engineering and Therapy (CICET), Columbia University Irving Medical College, New York, NY, USA., Beyaz S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. beyaz@cshl.edu., Amor C; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. amor@cshl.edu.; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. amor@cshl.edu.
Source: Nature aging [Nat Aging] 2026 Jan; Vol. 6 (1), pp. 108-126. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group US Country of Publication: United States NLM ID: 101773306 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-8465 (Electronic) Linking ISSN: 26628465 NLM ISO Abbreviation: Nat Aging Subsets: MEDLINE
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  Data: Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness.
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  Data: <searchLink fieldCode="AU" term="%22Eskiocak+O%22">Eskiocak O</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Gewolb+J%22">Gewolb J</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Shah+V%22">Shah V</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Rutgers New Jersey Medical School, Newark, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Rouse+JA%22">Rouse JA</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chowdhury+S%22">Chowdhury S</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Akyildiz+EO%22">Akyildiz EO</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Molecular and Translational Biomedicine Program, Institute of Natural and Applied Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.; Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.<br /><searchLink fieldCode="AU" term="%22Fernández-Maestre+I%22">Fernández-Maestre I</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Boyer+JA%22">Boyer JA</searchLink>; Lewis Sigler Institute for Integrative Genomics and Department of Chemistry, Princeton University, Princeton, NJ, USA.; Ludwig Institute for Cancer Research, Princeton Branch, Princeton, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Filliol+A%22">Filliol A</searchLink>; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Harris+AS%22">Harris AS</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Utama+R%22">Utama R</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Guo+G%22">Guo G</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Castro-Hernández+C%22">Castro-Hernández C</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Nnuji-John+E%22">Nnuji-John E</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Chung+C%22">Chung C</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA.<br /><searchLink fieldCode="AU" term="%22Anderson+A%22">Anderson A</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Flowers+S%22">Flowers S</searchLink>; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Habel+J%22">Habel J</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.<br /><searchLink fieldCode="AU" term="%22Romesser+PB%22">Romesser PB</searchLink>; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Levine+RL%22">Levine RL</searchLink>; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Lowe+SW%22">Lowe SW</searchLink>; Department of Cancer Biology and Genetics. Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sadelain+M%22">Sadelain M</searchLink>; Columbia Initiative in Cell Engineering and Therapy (CICET), Columbia University Irving Medical College, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Beyaz+S%22">Beyaz S</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. beyaz@cshl.edu.<br /><searchLink fieldCode="AU" term="%22Amor+C%22">Amor C</searchLink>; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. amor@cshl.edu.; Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. amor@cshl.edu.
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  Data: <searchLink fieldCode="JN" term="%22101773306%22">Nature aging</searchLink> [Nat Aging] 2026 Jan; Vol. 6 (1), pp. 108-126. <i>Date of Electronic Publication: </i>2025 Nov 25.
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