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Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth.

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Title: Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth.
Authors: França CT; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Pletnev S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Madan B; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA., Katsamba PS; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., McKee K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Morano NC; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Zhang B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Bahna F; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Bylund T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Louder MK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Mannepalli S; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Nimrania R; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA., O'Dell S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Kwong PD; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Shapiro L; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Sheng Z; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA., Zhou T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA., DeKosky BJ; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.; Department of Chemical Engineering, University of Kansas, Lawrence, KS 66045, USA.
Source: Vaccines [Vaccines (Basel)] 2025 Oct 27; Vol. 13 (11). Date of Electronic Publication: 2025 Oct 27.
Publication Type: Journal Article
Journal Info: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101629355 Publication Model: Electronic Cited Medium: Print ISSN: 2076-393X (Print) Linking ISSN: 2076393X NLM ISO Abbreviation: Vaccines (Basel) Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Yeast Display Reveals Plentiful Mutations That Improve Fusion Peptide Vaccine-Elicited Antibodies Beyond 59% HIV-1 Neutralization Breadth.
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  Data: <searchLink fieldCode="AU" term="%22França+CT%22">França CT</searchLink>; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Pletnev+S%22">Pletnev S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Madan+B%22">Madan B</searchLink>; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.<br /><searchLink fieldCode="AU" term="%22Katsamba+PS%22">Katsamba PS</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22McKee+K%22">McKee K</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Morano+NC%22">Morano NC</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Bahna+F%22">Bahna F</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Bylund+T%22">Bylund T</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Lin+BC%22">Lin BC</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Louder+MK%22">Louder MK</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Mannepalli+S%22">Mannepalli S</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Nimrania+R%22">Nimrania R</searchLink>; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.<br /><searchLink fieldCode="AU" term="%22O'Dell+S%22">O'Dell S</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Doria-Rose+NA%22">Doria-Rose NA</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22Kwong+PD%22">Kwong PD</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+L%22">Shapiro L</searchLink>; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Sheng+Z%22">Sheng Z</searchLink>; Aaron Diamond AIDS Research Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+T%22">Zhou T</searchLink>; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.<br /><searchLink fieldCode="AU" term="%22DeKosky+BJ%22">DeKosky BJ</searchLink>; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139, USA.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA.; Department of Chemical Engineering, University of Kansas, Lawrence, KS 66045, USA.
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  Data: <searchLink fieldCode="JN" term="%22101629355%22">Vaccines</searchLink> [Vaccines (Basel)] 2025 Oct 27; Vol. 13 (11). <i>Date of Electronic Publication: </i>2025 Oct 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22MDPI+AG%22">MDPI AG </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101629355 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2076-393X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222076393X%22">2076393X </searchLink><i>NLM ISO Abbreviation: </i>Vaccines (Basel) <i>Subsets: </i>PubMed not MEDLINE
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