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Lactococcus lactis expressing IL-6 supplementation promotes the Tr17 regulatory cell differentiation in the gut and alleviates the metabolic and inflammatory dysfunction in an experimental model of diet-induced type 2 diabetes.

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Title: Lactococcus lactis expressing IL-6 supplementation promotes the Tr17 regulatory cell differentiation in the gut and alleviates the metabolic and inflammatory dysfunction in an experimental model of diet-induced type 2 diabetes.
Authors: Pacheco TCF; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: thaillapacheco@usp.br., Barbosa SC; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: saracandidab@usp.br., Elias-Oliveira J; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: jeffersonelias@usp.br., Pereira ÍS; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: italo.biotecnologista@usp.br., Rodrigues VF; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: vanessa.fr@usp.br., Machado MSG; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: melissa.santana04@usp.br., Rios WM; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: wendy@usp.br., Dos Santos Ramos A; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto Medical School - University of Sao Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: andersonsramos@usp.br., Pereira JA; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: jessicaassis@usp.br., Nakama RP; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: nakamarp@usp.br., Tostes RC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: rtostes@usp.br., Bermudez-Humaran LG; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Insitute, Jouy-en-Josas, France. Electronic address: luis.bermudez@inra.fr., Carlos D; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: danicar@usp.br.
Source: Life sciences [Life Sci] 2026 Jan 01; Vol. 384, pp. 124112. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE
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  Data: Lactococcus lactis expressing IL-6 supplementation promotes the Tr17 regulatory cell differentiation in the gut and alleviates the metabolic and inflammatory dysfunction in an experimental model of diet-induced type 2 diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Pacheco+TCF%22">Pacheco TCF</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: thaillapacheco@usp.br.<br /><searchLink fieldCode="AU" term="%22Barbosa+SC%22">Barbosa SC</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: saracandidab@usp.br.<br /><searchLink fieldCode="AU" term="%22Elias-Oliveira+J%22">Elias-Oliveira J</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: jeffersonelias@usp.br.<br /><searchLink fieldCode="AU" term="%22Pereira+ÍS%22">Pereira ÍS</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: italo.biotecnologista@usp.br.<br /><searchLink fieldCode="AU" term="%22Rodrigues+VF%22">Rodrigues VF</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: vanessa.fr@usp.br.<br /><searchLink fieldCode="AU" term="%22Machado+MSG%22">Machado MSG</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: melissa.santana04@usp.br.<br /><searchLink fieldCode="AU" term="%22Rios+WM%22">Rios WM</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: wendy@usp.br.<br /><searchLink fieldCode="AU" term="%22Dos+Santos+Ramos+A%22">Dos Santos Ramos A</searchLink>; Center for Research in Inflammatory Diseases (CRID), Department of Pharmacology, Ribeirao Preto Medical School - University of Sao Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: andersonsramos@usp.br.<br /><searchLink fieldCode="AU" term="%22Pereira+JA%22">Pereira JA</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: jessicaassis@usp.br.<br /><searchLink fieldCode="AU" term="%22Nakama+RP%22">Nakama RP</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: nakamarp@usp.br.<br /><searchLink fieldCode="AU" term="%22Tostes+RC%22">Tostes RC</searchLink>; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: rtostes@usp.br.<br /><searchLink fieldCode="AU" term="%22Bermudez-Humaran+LG%22">Bermudez-Humaran LG</searchLink>; Université Paris-Saclay, INRAE, AgroParisTech, Micalis Insitute, Jouy-en-Josas, France. Electronic address: luis.bermudez@inra.fr.<br /><searchLink fieldCode="AU" term="%22Carlos+D%22">Carlos D</searchLink>; Laboratory of Immunoregulation of Metabolic Disease, Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address: danicar@usp.br.
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