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Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism.

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Title: Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism.
Authors: Willoughby OS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Nichenko AS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Brisendine MH; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Amiri N; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Institute for Critical Technology and Applied Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Henry SN; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Braxton DS; Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Brown JR; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Kraft BJ; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Jenkins KS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Addington AK; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Zaitsev AV; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA., Burrows ST; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA., McMillan RP; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Zhang H; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Tye SA; Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA., Najt CP; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA., Craige SE; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Translational Biology, Medicine, and Health Program, Virginia Tech, Roanoke, VA, 24016, USA., Rhoads TW; Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA., Warren JS; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Translational Biology, Medicine, and Health Program, Virginia Tech, Roanoke, VA, 24016, USA; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA., Drake JC; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Translational Biology, Medicine, and Health Program, Virginia Tech, Roanoke, VA, 24016, USA. Electronic address: joshuacd@vt.edu.
Source: Molecular metabolism [Mol Metab] 2026 Jan; Vol. 103, pp. 102288. Date of Electronic Publication: 2025 Nov 24.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
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  Data: Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism.
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  Data: <searchLink fieldCode="AU" term="%22Willoughby+OS%22">Willoughby OS</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Nichenko+AS%22">Nichenko AS</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Brisendine+MH%22">Brisendine MH</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Amiri+N%22">Amiri N</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Institute for Critical Technology and Applied Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Henry+SN%22">Henry SN</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Braxton+DS%22">Braxton DS</searchLink>; Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Brown+JR%22">Brown JR</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Kraft+BJ%22">Kraft BJ</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Jenkins+KS%22">Jenkins KS</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Addington+AK%22">Addington AK</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Zaitsev+AV%22">Zaitsev AV</searchLink>; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA.<br /><searchLink fieldCode="AU" term="%22Burrows+ST%22">Burrows ST</searchLink>; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA.<br /><searchLink fieldCode="AU" term="%22McMillan+RP%22">McMillan RP</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Tye+SA%22">Tye SA</searchLink>; Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Najt+CP%22">Najt CP</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.<br /><searchLink fieldCode="AU" term="%22Craige+SE%22">Craige SE</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Translational Biology, Medicine, and Health Program, Virginia Tech, Roanoke, VA, 24016, USA.<br /><searchLink fieldCode="AU" term="%22Rhoads+TW%22">Rhoads TW</searchLink>; Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI, USA.<br /><searchLink fieldCode="AU" term="%22Warren+JS%22">Warren JS</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Translational Biology, Medicine, and Health Program, Virginia Tech, Roanoke, VA, 24016, USA; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Tech, Roanoke, VA, USA.<br /><searchLink fieldCode="AU" term="%22Drake+JC%22">Drake JC</searchLink>; Department of Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Metabolism Core, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA; Translational Biology, Medicine, and Health Program, Virginia Tech, Roanoke, VA, 24016, USA. Electronic address: joshuacd@vt.edu.
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  Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2026 Jan; Vol. 103, pp. 102288. <i>Date of Electronic Publication: </i>2025 Nov 24.
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