Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial.
Saved in:
| Title: | Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial. |
|---|---|
| Authors: | Woodworth GF; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: gwoodworth@som.umaryland.edu., Anastasiadis P; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Ozair A; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada., Chabros J; Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA; Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA., Bettegowda C; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chen C; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA., Gerstl JVE; Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Douville C; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Mekary RA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, USA., Smith TR; Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Meng Y; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Hawkins C; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Pople CB; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada., Abrahao A; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Llinas M; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Heyn C; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Bunevicius A; Department of Neurology, Columbia University, New York, NY, USA., Rezai AR; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Neurosurgery, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA., Ball AJS; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Henry K; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA., Sahgal A; Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Torio E; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Ren H; Department of Mathematics and Statistics, University of Maryland, Baltimore, MD, USA., Ahmad H; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA., Arora H; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Eisenberg H; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA., Perry J; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Carpenter JS; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA., Hynynen K; Physical Sciences Platform, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., Pham LC; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA., Anketell MB; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Lim-Fat MJ; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada., Xu Z; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA., Cifarelli CP; Department of Neurosurgery, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA., Sheehan JP; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA., McDannold NJ; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA., Gandhi D; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Golby AJ; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA., Lipsman N; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. |
| Source: | The Lancet. Oncology [Lancet Oncol] 2025 Dec; Vol. 26 (12), pp. 1651-1664. |
| Publication Type: | Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study |
| Journal Info: | Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41308679 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Woodworth+GF%22">Woodworth GF</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: gwoodworth@som.umaryland.edu.<br /><searchLink fieldCode="AU" term="%22Anastasiadis+P%22">Anastasiadis P</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ozair+A%22">Ozair A</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA; Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.<br /><searchLink fieldCode="AU" term="%22Chabros+J%22">Chabros J</searchLink>; Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA; Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Bettegowda+C%22">Bettegowda C</searchLink>; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gerstl+JVE%22">Gerstl JVE</searchLink>; Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Douville+C%22">Douville C</searchLink>; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Mekary+RA%22">Mekary RA</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; School of Pharmacy, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Smith+TR%22">Smith TR</searchLink>; Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Meng+Y%22">Meng Y</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hawkins+C%22">Hawkins C</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pople+CB%22">Pople CB</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Abrahao+A%22">Abrahao A</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Llinas+M%22">Llinas M</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Heyn+C%22">Heyn C</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bunevicius+A%22">Bunevicius A</searchLink>; Department of Neurology, Columbia University, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Rezai+AR%22">Rezai AR</searchLink>; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA; Department of Neurosurgery, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Ball+AJS%22">Ball AJS</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Henry+K%22">Henry K</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Sahgal+A%22">Sahgal A</searchLink>; Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Torio+E%22">Torio E</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ren+H%22">Ren H</searchLink>; Department of Mathematics and Statistics, University of Maryland, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Ahmad+H%22">Ahmad H</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Arora+H%22">Arora H</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Eisenberg+H%22">Eisenberg H</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Perry+J%22">Perry J</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Carpenter+JS%22">Carpenter JS</searchLink>; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Hynynen+K%22">Hynynen K</searchLink>; Physical Sciences Platform, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Pham+LC%22">Pham LC</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Anketell+MB%22">Anketell MB</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lim-Fat+MJ%22">Lim-Fat MJ</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Xu+Z%22">Xu Z</searchLink>; Department of Neuroradiology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Cifarelli+CP%22">Cifarelli CP</searchLink>; Department of Neurosurgery, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.<br /><searchLink fieldCode="AU" term="%22Sheehan+JP%22">Sheehan JP</searchLink>; Department of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.<br /><searchLink fieldCode="AU" term="%22McDannold+NJ%22">McDannold NJ</searchLink>; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gandhi+D%22">Gandhi D</searchLink>; Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Golby+AJ%22">Golby AJ</searchLink>; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA; Department of Radiology, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lipsman+N%22">Lipsman N</searchLink>; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Neurosurgery, Department of Surgery, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2025 Dec; Vol. 26 (12), pp. 1651-1664. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Multicenter Study – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41308679 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S1470-2045(25)00492-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1651 Titles: – TitleFull: Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1/2 trial. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Woodworth GF – PersonEntity: Name: NameFull: Anastasiadis P – PersonEntity: Name: NameFull: Ozair A – PersonEntity: Name: NameFull: Chabros J – PersonEntity: Name: NameFull: Bettegowda C – PersonEntity: Name: NameFull: Chen C – PersonEntity: Name: NameFull: Gerstl JVE – PersonEntity: Name: NameFull: Douville C – PersonEntity: Name: NameFull: Mekary RA – PersonEntity: Name: NameFull: Smith TR – PersonEntity: Name: NameFull: Meng Y – PersonEntity: Name: NameFull: Hawkins C – PersonEntity: Name: NameFull: Pople CB – PersonEntity: Name: NameFull: Abrahao A – PersonEntity: Name: NameFull: Llinas M – PersonEntity: Name: NameFull: Heyn C – PersonEntity: Name: NameFull: Bunevicius A – PersonEntity: Name: NameFull: Rezai AR – PersonEntity: Name: NameFull: Ball AJS – PersonEntity: Name: NameFull: Henry K – PersonEntity: Name: NameFull: Sahgal A – PersonEntity: Name: NameFull: Torio E – PersonEntity: Name: NameFull: Ren H – PersonEntity: Name: NameFull: Ahmad H – PersonEntity: Name: NameFull: Arora H – PersonEntity: Name: NameFull: Eisenberg H – PersonEntity: Name: NameFull: Perry J – PersonEntity: Name: NameFull: Carpenter JS – PersonEntity: Name: NameFull: Hynynen K – PersonEntity: Name: NameFull: Pham LC – PersonEntity: Name: NameFull: Anketell MB – PersonEntity: Name: NameFull: Lim-Fat MJ – PersonEntity: Name: NameFull: Xu Z – PersonEntity: Name: NameFull: Cifarelli CP – PersonEntity: Name: NameFull: Sheehan JP – PersonEntity: Name: NameFull: McDannold NJ – PersonEntity: Name: NameFull: Gandhi D – PersonEntity: Name: NameFull: Golby AJ – PersonEntity: Name: NameFull: Lipsman N IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 2025 Dec Type: published Y: 2025 Identifiers: – Type: issn-electronic Value: 1474-5488 Numbering: – Type: volume Value: 26 – Type: issue Value: 12 Titles: – TitleFull: The Lancet. Oncology Type: main |
| ResultId | 1 |
