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Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion.

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Title: Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion.
Authors: Bejar MT; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK. mtb48@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. mtb48@cam.ac.uk., Jimenez-Gomez P; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Moutsopoulos I; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Ajith H; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Colom B; Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK., McGinn J; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK., Han S; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK., Skrupskelyte G; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Calero-Nieto FJ; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Göttgens B; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK., Mohorianu II; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK., Simons BD; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge, UK., Alcolea MP; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK. mpa28@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. mpa28@cam.ac.uk.
Source: Nature communications [Nat Commun] 2025 Nov 27; Vol. 16 (1), pp. 11305. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion.
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  Data: <searchLink fieldCode="AU" term="%22Bejar+MT%22">Bejar MT</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK. mtb48@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. mtb48@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Jimenez-Gomez+P%22">Jimenez-Gomez P</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Moutsopoulos+I%22">Moutsopoulos I</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ajith+H%22">Ajith H</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Colom+B%22">Colom B</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22McGinn+J%22">McGinn J</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Skrupskelyte+G%22">Skrupskelyte G</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Calero-Nieto+FJ%22">Calero-Nieto FJ</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Göttgens+B%22">Göttgens B</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Department of Haematology, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Mohorianu+II%22">Mohorianu II</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Simons+BD%22">Simons BD</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Wilberforce Road, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Alcolea+MP%22">Alcolea MP</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge, UK. mpa28@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. mpa28@cam.ac.uk.
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