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Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates.

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Title: Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates.
Authors: Kowalewski J; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France., Deutscher R; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany., Richardoz M; Virulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, Nîmes, France., Tomaszczyk M; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France., Gelin M; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France., Labesse G; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France., Hausch F; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.; Centre for Synthetic Biology, Technical University of Darmstadt, Darmstadt, Germany., Wright GD; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada., Dunyach-Remy C; Virulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, Nîmes, France., Guichou JF; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France., Lionne C; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France. corinne.lionne@cnrs.fr.
Source: Communications chemistry [Commun Chem] 2025 Nov 27; Vol. 8 (1), pp. 417. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem Subsets: PubMed not MEDLINE
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  Data: Fragment-based drug design of a bacterial kinase inhibitor capable of increasing the antibiotic sensitivity of clinical isolates.
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  Data: <searchLink fieldCode="AU" term="%22Kowalewski+J%22">Kowalewski J</searchLink>; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Deutscher+R%22">Deutscher R</searchLink>; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Richardoz+M%22">Richardoz M</searchLink>; Virulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, Nîmes, France.<br /><searchLink fieldCode="AU" term="%22Tomaszczyk+M%22">Tomaszczyk M</searchLink>; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Gelin+M%22">Gelin M</searchLink>; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Labesse+G%22">Labesse G</searchLink>; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Hausch+F%22">Hausch F</searchLink>; Institute for Organic Chemistry and Biochemistry, Technical University of Darmstadt, Darmstadt, Germany.; Centre for Synthetic Biology, Technical University of Darmstadt, Darmstadt, Germany.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Dunyach-Remy+C%22">Dunyach-Remy C</searchLink>; Virulence Bactérienne et Infections Chroniques, INSERM U1047, Department of Microbiology and Hospital Hygiene, University of Montpellier, Nîmes, France.<br /><searchLink fieldCode="AU" term="%22Guichou+JF%22">Guichou JF</searchLink>; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France.<br /><searchLink fieldCode="AU" term="%22Lionne+C%22">Lionne C</searchLink>; Centre de Biologie Structurale (CBS), University of Montpellier, CNRS UMR 5048, INSERM U1054, Montpellier, France. corinne.lionne@cnrs.fr.
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  Data: <searchLink fieldCode="JN" term="%22101725670%22">Communications chemistry</searchLink> [Commun Chem] 2025 Nov 27; Vol. 8 (1), pp. 417. <i>Date of Electronic Publication: </i>2025 Nov 27.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101725670 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2399-3669 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2223993669%22">23993669 </searchLink><i>NLM ISO Abbreviation: </i>Commun Chem <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2025 Nov 27
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