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A phase 1/2 study of DS-1594 menin inhibitor in relapsed/refractory acute leukemias.

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Title: A phase 1/2 study of DS-1594 menin inhibitor in relapsed/refractory acute leukemias.
Authors: Senapati J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Konopleva M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.; Department of Medical Oncology, Montefiore Einstein Cancer Center, New York, USA., Issa GC; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Jabbour E; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Kadia T; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., DiNardo C; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Borthakur G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Pemmaraju N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Short NJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Yilmaz M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Deshmukh I; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Alvarez J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Loghavi S; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Tang G; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA., Abbas HA; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Andreeff M; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Bhalla K; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Midde NM; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA., Said N; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA., Noyalis A; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA., Mires DE; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA., Ning J; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA., Xiao L; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA., Ravandi F; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Garcia-Manero G; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Kantarjian HM; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA., Daver NG; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA. ndaver@mdanderson.org.
Source: Journal of hematology & oncology [J Hematol Oncol] 2025 Nov 27; Vol. 18 (1), pp. 108. Date of Electronic Publication: 2025 Nov 27.
Publication Type: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Biomed Central Country of Publication: England NLM ID: 101468937 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-8722 (Electronic) Linking ISSN: 17568722 NLM ISO Abbreviation: J Hematol Oncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A phase 1/2 study of DS-1594 menin inhibitor in relapsed/refractory acute leukemias.
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  Data: <searchLink fieldCode="AU" term="%22Senapati+J%22">Senapati J</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Konopleva+M%22">Konopleva M</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.; Department of Medical Oncology, Montefiore Einstein Cancer Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Issa+GC%22">Issa GC</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Jabbour+E%22">Jabbour E</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kadia+T%22">Kadia T</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22DiNardo+C%22">DiNardo C</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Borthakur+G%22">Borthakur G</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Pemmaraju+N%22">Pemmaraju N</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Short+NJ%22">Short NJ</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Yilmaz+M%22">Yilmaz M</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Deshmukh+I%22">Deshmukh I</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Alvarez+J%22">Alvarez J</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Loghavi+S%22">Loghavi S</searchLink>; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Tang+G%22">Tang G</searchLink>; Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Abbas+HA%22">Abbas HA</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Andreeff+M%22">Andreeff M</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Bhalla+K%22">Bhalla K</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Midde+NM%22">Midde NM</searchLink>; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Said+N%22">Said N</searchLink>; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Noyalis+A%22">Noyalis A</searchLink>; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Mires+DE%22">Mires DE</searchLink>; Daiichi Sankyo, Inc, Basking Ridge, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Ning+J%22">Ning J</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, USA.<br /><searchLink fieldCode="AU" term="%22Ravandi+F%22">Ravandi F</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Manero+G%22">Garcia-Manero G</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Kantarjian+HM%22">Kantarjian HM</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Daver+NG%22">Daver NG</searchLink>; Department of Leukemia, The University of Texas MD Anderson Cancer Center, 77030, Houston, TX, USA. ndaver@mdanderson.org.
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  Data: <searchLink fieldCode="JN" term="%22101468937%22">Journal of hematology & oncology</searchLink> [J Hematol Oncol] 2025 Nov 27; Vol. 18 (1), pp. 108. <i>Date of Electronic Publication: </i>2025 Nov 27.
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  Data: Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase I; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Biomed+Central%22">Biomed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101468937 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1756-8722 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217568722%22">17568722 </searchLink><i>NLM ISO Abbreviation: </i>J Hematol Oncol <i>Subsets: </i>MEDLINE
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