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Multidimensional prognostic risk stratification of COPD exacerbations: the baseline, acuity, and trigger (BAt) model.

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Title: Multidimensional prognostic risk stratification of COPD exacerbations: the baseline, acuity, and trigger (BAt) model.
Authors: Aung HWW; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK., Vermeersch K; Research group BREATHE, KU Leuven, Leuven, Belgium., McAuley HJC; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK., Ramakrishnan S; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia; Institute for Respiratory Health, University of Western Australia, Perth, WA, Australia; University of Western Australia Medical School, Perth, WA, Australia., Abdo M; LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany; Internal Medicine Department, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany., Beersaerts A; Research group BREATHE, KU Leuven, Leuven, Belgium., Cass SP; King's Centre for Lung Health, School of Immunology and Microbial Sciences, King's College London, London, UK., Smallcombe N; King's Centre for Lung Health, School of Immunology and Microbial Sciences, King's College London, London, UK., Gyselinck I; Department of Respiratory Diseases, UZ Leuven, Leuven, Belgium., Pott H; Department of Medicine, Pulmonary, and Critical Care Medicine, Clinic for Airway Infections, University Medical Centre Marburg, Philipps-University Marburg, Marburg, Germany; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, DZL, Philipps-University Marburg, Marburg, Germany., Ward TJC; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK., Wright AKA; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK., Brightling CE; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK., Burgel PR; Department of Respiratory Medicine, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Cité, Paris, France., Contoli M; Azienda Ospedaliera Universitaria Ferrara and Azienda Unità Sanitaria Locale di Ferrara, Ferrara, Italy; Department of Translational Medicine, University of Ferrara, Ferrara, Italy., Franssen FME; Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, Netherlands., Huerta A; Emergency Department, Pulmonary and Critical Care Division, Clínica Sagrada Família, Universitat Internacional De Catalunya, Barcelona, Spain., Quint JK; School of Public Health, Imperial College London, London, UK., Schmeck B; Department of Respiratory Diseases, UZ Leuven, Leuven, Belgium; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, DZL, Philipps-University Marburg, Marburg, Germany., Vanfleteren LEGW; Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden., Waschki B; LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany; Department of Pulmonary Medicine, Itzehoe Hospital, Itzehoe, Germany., Watz H; LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany; Velocity Clinical Research Germany, Ahrensburg, Germany; University of Lübeck, ARCN, DZL, Lübeck, Germany., Bafadhel M; King's Centre for Lung Health, School of Immunology and Microbial Sciences, King's College London, London, UK., Janssens W; Research group BREATHE, KU Leuven, Leuven, Belgium; Department of Respiratory Diseases, UZ Leuven, Leuven, Belgium., Greening NJ; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK. Electronic address: neil.greening@leicester.ac.uk.
Corporate Authors: CICERO Consortium
Source: The Lancet. Respiratory medicine [Lancet Respir Med] 2026 Feb; Vol. 14 (2), pp. 174-186. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article; Review
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101605555 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2619 (Electronic) Linking ISSN: 22132600 NLM ISO Abbreviation: Lancet Respir Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Multidimensional prognostic risk stratification of COPD exacerbations: the baseline, acuity, and trigger (BAt) model.
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  Data: <searchLink fieldCode="AU" term="%22Aung+HWW%22">Aung HWW</searchLink>; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Vermeersch+K%22">Vermeersch K</searchLink>; Research group BREATHE, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22McAuley+HJC%22">McAuley HJC</searchLink>; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Ramakrishnan+S%22">Ramakrishnan S</searchLink>; Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia; Institute for Respiratory Health, University of Western Australia, Perth, WA, Australia; University of Western Australia Medical School, Perth, WA, Australia.<br /><searchLink fieldCode="AU" term="%22Abdo+M%22">Abdo M</searchLink>; LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany; Internal Medicine Department, University Medical Center Schleswig-Holstein Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Beersaerts+A%22">Beersaerts A</searchLink>; Research group BREATHE, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Cass+SP%22">Cass SP</searchLink>; King's Centre for Lung Health, School of Immunology and Microbial Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Smallcombe+N%22">Smallcombe N</searchLink>; King's Centre for Lung Health, School of Immunology and Microbial Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Gyselinck+I%22">Gyselinck I</searchLink>; Department of Respiratory Diseases, UZ Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Pott+H%22">Pott H</searchLink>; Department of Medicine, Pulmonary, and Critical Care Medicine, Clinic for Airway Infections, University Medical Centre Marburg, Philipps-University Marburg, Marburg, Germany; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, DZL, Philipps-University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Ward+TJC%22">Ward TJC</searchLink>; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Wright+AKA%22">Wright AKA</searchLink>; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Brightling+CE%22">Brightling CE</searchLink>; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK.<br /><searchLink fieldCode="AU" term="%22Burgel+PR%22">Burgel PR</searchLink>; Department of Respiratory Medicine, Cochin Hospital, Assistance Publique Hôpitaux de Paris, Paris, France; Université Paris Cité, Paris, France.<br /><searchLink fieldCode="AU" term="%22Contoli+M%22">Contoli M</searchLink>; Azienda Ospedaliera Universitaria Ferrara and Azienda Unità Sanitaria Locale di Ferrara, Ferrara, Italy; Department of Translational Medicine, University of Ferrara, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Franssen+FME%22">Franssen FME</searchLink>; Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, Netherlands.<br /><searchLink fieldCode="AU" term="%22Huerta+A%22">Huerta A</searchLink>; Emergency Department, Pulmonary and Critical Care Division, Clínica Sagrada Família, Universitat Internacional De Catalunya, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Quint+JK%22">Quint JK</searchLink>; School of Public Health, Imperial College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Schmeck+B%22">Schmeck B</searchLink>; Department of Respiratory Diseases, UZ Leuven, Leuven, Belgium; Institute for Lung Research, Universities of Giessen and Marburg Lung Center, DZL, Philipps-University Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Vanfleteren+LEGW%22">Vanfleteren LEGW</searchLink>; Department of Respiratory Medicine and Allergology, Sahlgrenska University Hospital, Gothenburg, Sweden.<br /><searchLink fieldCode="AU" term="%22Waschki+B%22">Waschki B</searchLink>; LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany; Department of Pulmonary Medicine, Itzehoe Hospital, Itzehoe, Germany.<br /><searchLink fieldCode="AU" term="%22Watz+H%22">Watz H</searchLink>; LungenClinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany; Velocity Clinical Research Germany, Ahrensburg, Germany; University of Lübeck, ARCN, DZL, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Bafadhel+M%22">Bafadhel M</searchLink>; King's Centre for Lung Health, School of Immunology and Microbial Sciences, King's College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Janssens+W%22">Janssens W</searchLink>; Research group BREATHE, KU Leuven, Leuven, Belgium; Department of Respiratory Diseases, UZ Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Greening+NJ%22">Greening NJ</searchLink>; Institute for Lung Health, National Institute for Health and Care Research Leicester Biomedical Research Centre (Respiratory), Glenfield Hospital, Leicester, UK; School of Medical Sciences, Division of Respiratory Sciences, University of Leicester, Leicester, UK. Electronic address: neil.greening@leicester.ac.uk.
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