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Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.

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Title: Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.
Authors: Musicha P; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Beale MA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Cocker D; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK., Oruru FA; Infectious Disease Institute, Makerere University, Kampala, Uganda., Zuza A; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Salifu C; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi., Katende G; Infectious Disease Institute, Makerere University, Kampala, Uganda., Nanono S; Infectious Disease Institute, Makerere University, Kampala, Uganda., Isaasi F; Infectious Disease Institute, Makerere University, Kampala, Uganda., Chidziwisano K; Malawi University of Business and Applied Sciences, Blantyre, Malawi., Mugisha L; College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Kajumbula H; College of Health Sciences, Makerere University, Kampala, Uganda., Musoke D; School of Public Health, Makerere University, Kampala, Uganda., Morse T; Department of Civil and Environmental Engineering, University of Strathclyde, Glasgow, UK., Jacob ST; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Walimu, Kampala, Uganda., Feasey NA; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; School of Medicine, University of St Andrews, St Andrews, UK., Thomson NR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: pm13@sanger.ac.uk.
Source: The Lancet. Microbe [Lancet Microbe] 2026 Jan; Vol. 7 (1), pp. 101224. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101769019 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-5247 (Electronic) Linking ISSN: 26665247 NLM ISO Abbreviation: Lancet Microbe Subsets: MEDLINE
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  Data: Transmission of extended spectrum β-lactamase-producing Escherichia coli and antimicrobial resistance gene flow across One Health compartments in eastern Africa: a whole-genome sequence analysis from a prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Musicha+P%22">Musicha P</searchLink>; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Beale+MA%22">Beale MA</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Cocker+D%22">Cocker D</searchLink>; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.<br /><searchLink fieldCode="AU" term="%22Oruru+FA%22">Oruru FA</searchLink>; Infectious Disease Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Zuza+A%22">Zuza A</searchLink>; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Salifu+C%22">Salifu C</searchLink>; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Katende+G%22">Katende G</searchLink>; Infectious Disease Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Nanono+S%22">Nanono S</searchLink>; Infectious Disease Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Isaasi+F%22">Isaasi F</searchLink>; Infectious Disease Institute, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Chidziwisano+K%22">Chidziwisano K</searchLink>; Malawi University of Business and Applied Sciences, Blantyre, Malawi.<br /><searchLink fieldCode="AU" term="%22Mugisha+L%22">Mugisha L</searchLink>; College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Kajumbula+H%22">Kajumbula H</searchLink>; College of Health Sciences, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Musoke+D%22">Musoke D</searchLink>; School of Public Health, Makerere University, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Morse+T%22">Morse T</searchLink>; Department of Civil and Environmental Engineering, University of Strathclyde, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Jacob+ST%22">Jacob ST</searchLink>; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; Walimu, Kampala, Uganda.<br /><searchLink fieldCode="AU" term="%22Feasey+NA%22">Feasey NA</searchLink>; Malawi Liverpool Wellcome Research Programme, Kamuzu University of Health Sciences, Blantyre, Malawi; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK; School of Medicine, University of St Andrews, St Andrews, UK.<br /><searchLink fieldCode="AU" term="%22Thomson+NR%22">Thomson NR</searchLink>; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK; London School of Hygiene & Tropical Medicine, London, UK. Electronic address: pm13@sanger.ac.uk.
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