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Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.

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Title: Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.
Authors: Aguilar F; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Universitat de Barcelona (UB), Barcelona, Spain., Lozano JJ; Bioinformatics Platform, CIBER of Hepatic and Digestive Diseases (CIBERehd), Barcelona, Spain., Clària J; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Biochemistry and Molecular Genetics Service, Hospital Clínic-IDIBAPS-CIBERehd, Barcelona, Spain; Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain., Reinartz Groba SN; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany; Department of Internal Medicine B, University of Münster, Münster, Germany., Richter M; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany., Jiménez-Gracia L; Universitat de Barcelona (UB), Barcelona, Spain; Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain., Grange P; GenoSplice, Paris, France., Jolly A; GenoSplice, Paris, France., Praktiknjo M; Department of Internal Medicine B, University of Münster, Münster, Germany., Sánchez-Garrido C; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain., Uson Raposo EM; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain., García-Torre B; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain., Laleman W; Department of Gastroenterology & Hepatology, Section of Liver & Biliopancreatic disorders and Liver Transplantation, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Gómez-Cabrero D; Translational Bioinformatics Unit, Navarrabiomed, Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia., Palomino-Echeverria S; Translational Bioinformatics Unit, Navarrabiomed, Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki Institute for Life Sciences, University of Helsinki, Helsinki, Finland., Iglesias EH; Translational Bioinformatics Unit, Navarrabiomed, Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain., Farias AQ; Department of Gastroenterology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil., Marciano S; Liver Unit and Department of Research, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Caraceni P; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliera-Universitaria di Bologna, Italy., Trebicka J; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Department of Internal Medicine B, University of Münster, Münster, Germany., Cerutti A; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain; Translational Clinical Research Program, Hospital del Mar Research Institute, Barcelona, Spain., Arroyo V; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain., Heyn H; Universitat de Barcelona (UB), Barcelona, Spain; Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain., Nieto JC; Universitat de Barcelona (UB), Barcelona, Spain; Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain., Soehnlein O; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany., Rautou PE; Université Paris-Cité, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France; AP-HP, Hôpital Beaujon, Service d'Hépatologie, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France., Moreau R; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Université Paris-Cité, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France; AP-HP, Hôpital Beaujon, Service d'Hépatologie, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France. Electronic address: richard.moreau@efclif.com.
Corporate Authors: DECISION Consortium
Source: Journal of hepatology [J Hepatol] 2026 Apr; Vol. 84 (4), pp. 749-765. Date of Electronic Publication: 2025 Nov 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis.
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  Data: <searchLink fieldCode="AU" term="%22Aguilar+F%22">Aguilar F</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Universitat de Barcelona (UB), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Lozano+JJ%22">Lozano JJ</searchLink>; Bioinformatics Platform, CIBER of Hepatic and Digestive Diseases (CIBERehd), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Clària+J%22">Clària J</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Biochemistry and Molecular Genetics Service, Hospital Clínic-IDIBAPS-CIBERehd, Barcelona, Spain; Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Reinartz+Groba+SN%22">Reinartz Groba SN</searchLink>; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany; Department of Internal Medicine B, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Richter+M%22">Richter M</searchLink>; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Jiménez-Gracia+L%22">Jiménez-Gracia L</searchLink>; Universitat de Barcelona (UB), Barcelona, Spain; Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Grange+P%22">Grange P</searchLink>; GenoSplice, Paris, France.<br /><searchLink fieldCode="AU" term="%22Jolly+A%22">Jolly A</searchLink>; GenoSplice, Paris, France.<br /><searchLink fieldCode="AU" term="%22Praktiknjo+M%22">Praktiknjo M</searchLink>; Department of Internal Medicine B, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Sánchez-Garrido+C%22">Sánchez-Garrido C</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Uson+Raposo+EM%22">Uson Raposo EM</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22García-Torre+B%22">García-Torre B</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Laleman+W%22">Laleman W</searchLink>; Department of Gastroenterology & Hepatology, Section of Liver & Biliopancreatic disorders and Liver Transplantation, University Hospitals Leuven, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Gómez-Cabrero+D%22">Gómez-Cabrero D</searchLink>; Translational Bioinformatics Unit, Navarrabiomed, Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; Biological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Palomino-Echeverria+S%22">Palomino-Echeverria S</searchLink>; Translational Bioinformatics Unit, Navarrabiomed, Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain; Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland; Institute for Molecular Medicine Finland, Helsinki Institute for Life Sciences, University of Helsinki, Helsinki, Finland.<br /><searchLink fieldCode="AU" term="%22Iglesias+EH%22">Iglesias EH</searchLink>; Translational Bioinformatics Unit, Navarrabiomed, Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Farias+AQ%22">Farias AQ</searchLink>; Department of Gastroenterology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Marciano+S%22">Marciano S</searchLink>; Liver Unit and Department of Research, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.<br /><searchLink fieldCode="AU" term="%22Caraceni+P%22">Caraceni P</searchLink>; Department of Medical and Surgical Science, University of Bologna, Bologna, Italy; IRCCS Azienda Ospedaliera-Universitaria di Bologna, Italy.<br /><searchLink fieldCode="AU" term="%22Trebicka+J%22">Trebicka J</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Department of Internal Medicine B, University of Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Cerutti+A%22">Cerutti A</searchLink>; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain; Translational Clinical Research Program, Hospital del Mar Research Institute, Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Arroyo+V%22">Arroyo V</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Heyn+H%22">Heyn H</searchLink>; Universitat de Barcelona (UB), Barcelona, Spain; Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain; Catalan Institute for Research and Advanced Studies (ICREA), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Nieto+JC%22">Nieto JC</searchLink>; Universitat de Barcelona (UB), Barcelona, Spain; Centre Nacional d'Anàlisi Genòmica (CNAG), Barcelona, Spain.<br /><searchLink fieldCode="AU" term="%22Soehnlein+O%22">Soehnlein O</searchLink>; Institute of Experimental Pathology (ExPat), Center of Molecular Biology of Inflammation (ZMBE), Von-Esmarch-Str. 56, University of Münster, 48149 Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Rautou+PE%22">Rautou PE</searchLink>; Université Paris-Cité, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France; AP-HP, Hôpital Beaujon, Service d'Hépatologie, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France.<br /><searchLink fieldCode="AU" term="%22Moreau+R%22">Moreau R</searchLink>; European Foundation for the Study of Chronic Liver Failure (EF CLIF), Barcelona, Spain; Université Paris-Cité, Inserm, Centre de recherche sur l'inflammation, UMR 1149, Paris, France; AP-HP, Hôpital Beaujon, Service d'Hépatologie, DMU DIGEST, Centre de Référence des Maladies Vasculaires du Foie, FILFOIE, ERN RARE-LIVER, Clichy, France. Electronic address: richard.moreau@efclif.com.
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