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Chemically Cross-Linked Nanocapsules from Terpolymers of Polyethylene Glycol-Polylactide with Cationic Pendent Groups for Pgp-siRNA and Doxorubicin Codelivery in Overcoming Multidrug Resistance in Breast Cancer.

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Title: Chemically Cross-Linked Nanocapsules from Terpolymers of Polyethylene Glycol-Polylactide with Cationic Pendent Groups for Pgp-siRNA and Doxorubicin Codelivery in Overcoming Multidrug Resistance in Breast Cancer.
Authors: Lin ZI; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Department of Medical Education and Research, Kaohsiung Veterans General Hospital Kaohsiung, Kaohsiung 81362, Taiwan., Tsai TH; Division of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan., Wu LH; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan., Lu CH; Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan., Hsu CY; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Liang H; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China., Lin HY; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Fang YP; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.; Regenerative Medical and Cell Therapy Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan., Law WC; Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, P. R. China., Chang CH; Division of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan., Liou HE; Division of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan., Yang C; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.; The Shenzhen Key Laboratory of Metabolism and Cardiovascular Homeostasis, Shenzhen University, Shenzhen 518060, China., Cheng PW; Department of Medical Education and Research, Kaohsiung Veterans General Hospital Kaohsiung, Kaohsiung 81362, Taiwan.; Department of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan., Lee CH; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; College of Semiconductor and Advanced Technology Research, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan., Chen CK; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
Source: Molecular pharmaceutics [Mol Pharm] 2026 Jan 05; Vol. 23 (1), pp. 79-102. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Chemically Cross-Linked Nanocapsules from Terpolymers of Polyethylene Glycol-Polylactide with Cationic Pendent Groups for Pgp-siRNA and Doxorubicin Codelivery in Overcoming Multidrug Resistance in Breast Cancer.
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  Data: <searchLink fieldCode="AU" term="%22Lin+ZI%22">Lin ZI</searchLink>; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.; Department of Medical Education and Research, Kaohsiung Veterans General Hospital Kaohsiung, Kaohsiung 81362, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+TH%22">Tsai TH</searchLink>; Division of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wu+LH%22">Wu LH</searchLink>; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+CH%22">Lu CH</searchLink>; Department of Fiber and Composite Materials, Feng Chia University, Taichung 40724, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hsu+CY%22">Hsu CY</searchLink>; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liang+H%22">Liang H</searchLink>; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lin+HY%22">Lin HY</searchLink>; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Fang+YP%22">Fang YP</searchLink>; School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.; Regenerative Medical and Cell Therapy Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.<br /><searchLink fieldCode="AU" term="%22Law+WC%22">Law WC</searchLink>; Department of Industrial and Systems Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong 999077, P. R. China.<br /><searchLink fieldCode="AU" term="%22Chang+CH%22">Chang CH</searchLink>; Division of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liou+HE%22">Liou HE</searchLink>; Division of Cardiology and Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi 60002, Taiwan.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong 518060, P. R. China.; The Shenzhen Key Laboratory of Metabolism and Cardiovascular Homeostasis, Shenzhen University, Shenzhen 518060, China.<br /><searchLink fieldCode="AU" term="%22Cheng+PW%22">Cheng PW</searchLink>; Department of Medical Education and Research, Kaohsiung Veterans General Hospital Kaohsiung, Kaohsiung 81362, Taiwan.; Department of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lee+CH%22">Lee CH</searchLink>; Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Aerosol Science Research Center, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; College of Semiconductor and Advanced Technology Research, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404327, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CK%22">Chen CK</searchLink>; Polymeric Biomaterials Laboratory, Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
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  Data: <searchLink fieldCode="JN" term="%22101197791%22">Molecular pharmaceutics</searchLink> [Mol Pharm] 2026 Jan 05; Vol. 23 (1), pp. 79-102. <i>Date of Electronic Publication: </i>2025 Nov 28.
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        Value: 10.1021/acs.molpharmaceut.4c00600
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        Text: English
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      – TitleFull: Chemically Cross-Linked Nanocapsules from Terpolymers of Polyethylene Glycol-Polylactide with Cationic Pendent Groups for Pgp-siRNA and Doxorubicin Codelivery in Overcoming Multidrug Resistance in Breast Cancer.
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              Text: 2026 Jan 05
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