A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes.
Saved in:
| Title: | A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes. |
|---|---|
| Authors: | Srivastava N; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Vomund AN; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Yu R; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Peterson OJ; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Yang Y; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Turicek DP; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Abousaway O; Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA., Li T; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA., Kain L; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Stone P; Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St. Louis, MO, USA., Ansar A; Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St. Louis, MO, USA., Clement CC; Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA., Sharma S; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Melhem R; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA., Zhang B; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA., Liu C; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA., Joglekar AV; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Hu H; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA., Hsieh CS; Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA., Campisi L; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA., Santambrogio L; Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Teyton L; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA., Unanue ER; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA., Arbelaez AM; Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St. Louis, MO, USA., Lichti CF; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA. clichti@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA. clichti@wustl.edu., Wan X; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA. wanx@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA. wanx@wustl.edu. |
| Source: | Nature immunology [Nat Immunol] 2026 Jan; Vol. 27 (1), pp. 82-97. Date of Electronic Publication: 2025 Nov 28. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
|---|---|
| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41315082 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Srivastava+N%22">Srivastava N</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Vomund+AN%22">Vomund AN</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yu+R%22">Yu R</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Peterson+OJ%22">Peterson OJ</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Turicek+DP%22">Turicek DP</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Abousaway+O%22">Abousaway O</searchLink>; Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Li+T%22">Li T</searchLink>; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Kain+L%22">Kain L</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Stone+P%22">Stone P</searchLink>; Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Ansar+A%22">Ansar A</searchLink>; Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Clement+CC%22">Clement CC</searchLink>; Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Sharma+S%22">Sharma S</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Melhem+R%22">Melhem R</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+B%22">Zhang B</searchLink>; Department of Developmental Biology, Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Joglekar+AV%22">Joglekar AV</searchLink>; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Hsieh+CS%22">Hsieh CS</searchLink>; Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Campisi+L%22">Campisi L</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Santambrogio+L%22">Santambrogio L</searchLink>; Department of Radiation Oncology, Weill Cornell Medicine, New York, NY, USA.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Teyton+L%22">Teyton L</searchLink>; Department of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Unanue+ER%22">Unanue ER</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Arbelaez+AM%22">Arbelaez AM</searchLink>; Department of Pediatrics, Division of Endocrinology, Diabetes, and Metabolism, Washington University School of Medicine, St. Louis, MO, USA.<br /><searchLink fieldCode="AU" term="%22Lichti+CF%22">Lichti CF</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA. clichti@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA. clichti@wustl.edu.<br /><searchLink fieldCode="AU" term="%22Wan+X%22">Wan X</searchLink>; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, MO, USA. wanx@wustl.edu.; The Andrew M. and Jane M. Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA. wanx@wustl.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100941354%22">Nature immunology</searchLink> [Nat Immunol] 2026 Jan; Vol. 27 (1), pp. 82-97. <i>Date of Electronic Publication: </i>2025 Nov 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+America+Inc%22">Nature America Inc </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100941354 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1529-2916 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215292908%22">15292908 </searchLink><i>NLM ISO Abbreviation: </i>Nat Immunol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41315082 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41590-025-02343-z Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 82 Titles: – TitleFull: A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Srivastava N – PersonEntity: Name: NameFull: Vomund AN – PersonEntity: Name: NameFull: Yu R – PersonEntity: Name: NameFull: Peterson OJ – PersonEntity: Name: NameFull: Yang Y – PersonEntity: Name: NameFull: Turicek DP – PersonEntity: Name: NameFull: Abousaway O – PersonEntity: Name: NameFull: Li T – PersonEntity: Name: NameFull: Kain L – PersonEntity: Name: NameFull: Stone P – PersonEntity: Name: NameFull: Ansar A – PersonEntity: Name: NameFull: Clement CC – PersonEntity: Name: NameFull: Sharma S – PersonEntity: Name: NameFull: Melhem R – PersonEntity: Name: NameFull: Zhang B – PersonEntity: Name: NameFull: Liu C – PersonEntity: Name: NameFull: Joglekar AV – PersonEntity: Name: NameFull: Hu H – PersonEntity: Name: NameFull: Hsieh CS – PersonEntity: Name: NameFull: Campisi L – PersonEntity: Name: NameFull: Santambrogio L – PersonEntity: Name: NameFull: Teyton L – PersonEntity: Name: NameFull: Unanue ER – PersonEntity: Name: NameFull: Arbelaez AM – PersonEntity: Name: NameFull: Lichti CF – PersonEntity: Name: NameFull: Wan X IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: 2026 Jan Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1529-2916 Numbering: – Type: volume Value: 27 – Type: issue Value: 1 Titles: – TitleFull: Nature immunology Type: main |
| ResultId | 1 |
