Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy.
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| Title: | Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy. |
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| Authors: | Delehouzé C; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France.; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France., Mallais M; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada., Comte A; Université de Lyon, CNRS UMR 5246, ICBMS, Chimiothèque, Université Claude Bernard Lyon 1, F-69622, Villeurbanne, France., Lucas R; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France., Baratte B; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France.; Sorbonne Université, CNRS, Kinase Inhibitor Specialized Screening facility, KISSf, F-29680, Roscoff, France., Bélal S; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France., Autret A; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France., Py N; Neuron Experts, Cité de la cosmétique, 2 rue Odette Jasse, 13015, Marseille, France., Steinschneider R; Neuron Experts, Cité de la cosmétique, 2 rue Odette Jasse, 13015, Marseille, France., Adoux L; Plateforme GenomIC, Université de Paris, Institut Cochin, INSERM-CNRS, F-75014, Paris, France., Saintpierre B; Plateforme GenomIC, Université de Paris, Institut Cochin, INSERM-CNRS, F-75014, Paris, France., Letourneur F; Plateforme GenomIC, Université de Paris, Institut Cochin, INSERM-CNRS, F-75014, Paris, France., Robert T; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France.; Sorbonne Université, CNRS, Kinase Inhibitor Specialized Screening facility, KISSf, F-29680, Roscoff, France., Cougoule C; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Bomfim C; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Planès R; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Péricat D; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Bulinski JC; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France., Dimanche-Boitrel MT; France Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France., Goekjian P; Université de Lyon, CNRS UMR 5246, ICBMS, Laboratoire Chimie Organique 2-Glycosciences, Université Claude Bernard Lyon 1, F-69622, Villeurbanne, France., Meunier E; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France., Rousselot M; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France., Pratt DA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada., Bach S; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France. bach@sb-roscoff.fr.; Sorbonne Université, CNRS, Kinase Inhibitor Specialized Screening facility, KISSf, F-29680, Roscoff, France. bach@sb-roscoff.fr. |
| Source: | Cell death discovery [Cell Death Discov] 2025 Nov 28; Vol. 11 (1), pp. 552. Date of Electronic Publication: 2025 Nov 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41315180 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Delehouzé+C%22">Delehouzé C</searchLink>; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France.; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Mallais+M%22">Mallais M</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Comte+A%22">Comte A</searchLink>; Université de Lyon, CNRS UMR 5246, ICBMS, Chimiothèque, Université Claude Bernard Lyon 1, F-69622, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Lucas+R%22">Lucas R</searchLink>; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Baratte+B%22">Baratte B</searchLink>; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France.; Sorbonne Université, CNRS, Kinase Inhibitor Specialized Screening facility, KISSf, F-29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Bélal+S%22">Bélal S</searchLink>; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Autret+A%22">Autret A</searchLink>; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Py+N%22">Py N</searchLink>; Neuron Experts, Cité de la cosmétique, 2 rue Odette Jasse, 13015, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Steinschneider+R%22">Steinschneider R</searchLink>; Neuron Experts, Cité de la cosmétique, 2 rue Odette Jasse, 13015, Marseille, France.<br /><searchLink fieldCode="AU" term="%22Adoux+L%22">Adoux L</searchLink>; Plateforme GenomIC, Université de Paris, Institut Cochin, INSERM-CNRS, F-75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Saintpierre+B%22">Saintpierre B</searchLink>; Plateforme GenomIC, Université de Paris, Institut Cochin, INSERM-CNRS, F-75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Letourneur+F%22">Letourneur F</searchLink>; Plateforme GenomIC, Université de Paris, Institut Cochin, INSERM-CNRS, F-75014, Paris, France.<br /><searchLink fieldCode="AU" term="%22Robert+T%22">Robert T</searchLink>; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France.; Sorbonne Université, CNRS, Kinase Inhibitor Specialized Screening facility, KISSf, F-29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Cougoule+C%22">Cougoule C</searchLink>; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Bomfim+C%22">Bomfim C</searchLink>; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Planès+R%22">Planès R</searchLink>; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Péricat+D%22">Péricat D</searchLink>; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Bulinski+JC%22">Bulinski JC</searchLink>; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Dimanche-Boitrel+MT%22">Dimanche-Boitrel MT</searchLink>; France Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en santé, environnement et travail) - UMR&#95;S 1085, F-35000, Rennes, France.<br /><searchLink fieldCode="AU" term="%22Goekjian+P%22">Goekjian P</searchLink>; Université de Lyon, CNRS UMR 5246, ICBMS, Laboratoire Chimie Organique 2-Glycosciences, Université Claude Bernard Lyon 1, F-69622, Villeurbanne, France.<br /><searchLink fieldCode="AU" term="%22Meunier+E%22">Meunier E</searchLink>; Institut de Pharmacologie et Biologie Structurale (IPBS), Université de Toulouse, CNRS, Toulouse, France.<br /><searchLink fieldCode="AU" term="%22Rousselot+M%22">Rousselot M</searchLink>; SeaBeLife Biotech, Place Georges Teissier, 29680, Roscoff, France.<br /><searchLink fieldCode="AU" term="%22Pratt+DA%22">Pratt DA</searchLink>; Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bach+S%22">Bach S</searchLink>; Sorbonne Université, CNRS, Laboratoire de Biologie Intégrative des Modèles Marins, LBI2M, F-29680, Roscoff, France. bach@sb-roscoff.fr.; Sorbonne Université, CNRS, Kinase Inhibitor Specialized Screening facility, KISSf, F-29680, Roscoff, France. bach@sb-roscoff.fr. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2025 Nov 28; Vol. 11 (1), pp. 552. <i>Date of Electronic Publication: </i>2025 Nov 28. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41315180 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41420-025-02852-8 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 552 Titles: – TitleFull: Sibiriline, a novel dual inhibitor of necroptosis and ferroptosis, prevents RIPK1 kinase activity and (phospho)lipid peroxidation as a potential therapeutic strategy. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Delehouzé C – PersonEntity: Name: NameFull: Mallais M – PersonEntity: Name: NameFull: Comte A – PersonEntity: Name: NameFull: Lucas R – PersonEntity: Name: NameFull: Baratte B – PersonEntity: Name: NameFull: Bélal S – PersonEntity: Name: NameFull: Autret A – PersonEntity: Name: NameFull: Py N – PersonEntity: Name: NameFull: Steinschneider R – PersonEntity: Name: NameFull: Adoux L – PersonEntity: Name: NameFull: Saintpierre B – PersonEntity: Name: NameFull: Letourneur F – PersonEntity: Name: NameFull: Robert T – PersonEntity: Name: NameFull: Cougoule C – PersonEntity: Name: NameFull: Bomfim C – PersonEntity: Name: NameFull: Planès R – PersonEntity: Name: NameFull: Péricat D – PersonEntity: Name: NameFull: Bulinski JC – PersonEntity: Name: NameFull: Dimanche-Boitrel MT – PersonEntity: Name: NameFull: Goekjian P – PersonEntity: Name: NameFull: Meunier E – PersonEntity: Name: NameFull: Rousselot M – PersonEntity: Name: NameFull: Pratt DA – PersonEntity: Name: NameFull: Bach S IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 11 Text: 2025 Nov 28 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 2058-7716 Numbering: – Type: volume Value: 11 – Type: issue Value: 1 Titles: – TitleFull: Cell death discovery Type: main |
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