A niche-dependent redox rheostat regulates epithelial stem cell fate.
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| Title: | A niche-dependent redox rheostat regulates epithelial stem cell fate. |
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| Authors: | Chen X; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Raghunathan K; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Bao B; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Ngwa E; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Kwong A; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Wu Z; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Babcock S; Department of Pathology, Brigham and Women's Hospital Harvard Medical School, Boston, MA, USA., Baek C; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Ye G; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Muppirala A; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Peng Q; Department of Chemistry, Boston College, Chestnut Hill, MA, USA., Rutlin M; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Bhaumik M; Department of Neurology, F.M. Kirby Neurobiology Center, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA., Yang D; Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China., Kotlarz D; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Child and Adolescent Health (DZKJ), partner site Munich, Munich, Germany., Jadhav U; Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Rao M; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA., Weerapana E; Department of Chemistry, Boston College, Chestnut Hill, MA, USA., Zhou X; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Ordovas-Montanes J; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA.; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA., Snapper SB; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA, USA., Thiagarajah JR; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital; Harvard Medical School, Boston, MA, USA. jay.thiagarajah@childrens.harvard.edu.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA, USA. jay.thiagarajah@childrens.harvard.edu.; Congenital Enteropathy Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. jay.thiagarajah@childrens.harvard.edu. |
| Source: | Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 11713. Date of Electronic Publication: 2025 Nov 28. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-025-66636-5 |
