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Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure.

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Title: Genome-wide gene-environment interaction study uncovers 162 vitamin D status variants using a precise ambient UVB measure.
Authors: Shraim R; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland.; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; The Research Ireland Centre for Research Training in Genomics Data Sciences, University of Galway, Galway, Ireland., Timofeeva M; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Danish Institute for Advanced Study, University of Southern Denmark, Odense, Denmark., Wyse C; Department of Biology, Maynooth University, Kildare, Ireland.; The Kathleen Lonsdale Human Health Institute, Maynooth University, Kildare, Ireland., van Geffen J; Royal Netherlands Meteorological Institute, 3731, GA De Bilt, The Netherlands., van Weele M; Royal Netherlands Meteorological Institute, 3731, GA De Bilt, The Netherlands., Romero-Ortuno R; Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland., Lopez LM; Department of Biology, Maynooth University, Kildare, Ireland.; The Kathleen Lonsdale Human Health Institute, Maynooth University, Kildare, Ireland.; FutureNeuro Research Ireland Centre, Department of Biology, Maynooth University, Maynooth Co., Kildare, Ireland., Kleber ME; SYNLAB MVZ für Humangenetik, Mannheim, Germany., Pilz S; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria., März W; SYNLAB MVZ für Humangenetik, Mannheim, Germany.; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany.; Medical Clinic III (Cardiology, Angiology, Pneumology), University of Heidelberg, Heidelberg, Germany., Fletcher BS; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK., Wilson JF; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK., Theodoratou E; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK., Dunlop MG; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McManus R; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland., Zgaga L; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland. zgagal@tcd.ie.
Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 10774. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Shraim+R%22">Shraim R</searchLink>; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland.; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.; The Research Ireland Centre for Research Training in Genomics Data Sciences, University of Galway, Galway, Ireland.<br /><searchLink fieldCode="AU" term="%22Timofeeva+M%22">Timofeeva M</searchLink>; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.; Danish Institute for Advanced Study, University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Wyse+C%22">Wyse C</searchLink>; Department of Biology, Maynooth University, Kildare, Ireland.; The Kathleen Lonsdale Human Health Institute, Maynooth University, Kildare, Ireland.<br /><searchLink fieldCode="AU" term="%22van+Geffen+J%22">van Geffen J</searchLink>; Royal Netherlands Meteorological Institute, 3731, GA De Bilt, The Netherlands.<br /><searchLink fieldCode="AU" term="%22van+Weele+M%22">van Weele M</searchLink>; Royal Netherlands Meteorological Institute, 3731, GA De Bilt, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Romero-Ortuno+R%22">Romero-Ortuno R</searchLink>; Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland.; Mercer's Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Lopez+LM%22">Lopez LM</searchLink>; Department of Biology, Maynooth University, Kildare, Ireland.; The Kathleen Lonsdale Human Health Institute, Maynooth University, Kildare, Ireland.; FutureNeuro Research Ireland Centre, Department of Biology, Maynooth University, Maynooth Co., Kildare, Ireland.<br /><searchLink fieldCode="AU" term="%22Kleber+ME%22">Kleber ME</searchLink>; SYNLAB MVZ für Humangenetik, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Pilz+S%22">Pilz S</searchLink>; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.<br /><searchLink fieldCode="AU" term="%22März+W%22">März W</searchLink>; SYNLAB MVZ für Humangenetik, Mannheim, Germany.; SYNLAB Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Germany.; Medical Clinic III (Cardiology, Angiology, Pneumology), University of Heidelberg, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Fletcher+BS%22">Fletcher BS</searchLink>; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Wilson+JF%22">Wilson JF</searchLink>; Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, Scotland, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, Scotland, UK.<br /><searchLink fieldCode="AU" term="%22Theodoratou+E%22">Theodoratou E</searchLink>; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.; Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22Dunlop+MG%22">Dunlop MG</searchLink>; Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.; Cancer Research UK Edinburgh Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.<br /><searchLink fieldCode="AU" term="%22McManus+R%22">McManus R</searchLink>; Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.<br /><searchLink fieldCode="AU" term="%22Zgaga+L%22">Zgaga L</searchLink>; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, Dublin, Ireland. zgagal@tcd.ie.
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