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Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation.

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Title: Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation.
Authors: Guan PL; College of Life Sciences, Zhejiang University, Hangzhou, China.; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China., Yuan CD; Department of Dermatology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P.R. China., Han MY; Institute for immunity, Transplantation and Infection, Stanford Medicine, Stanford University, 1215 Welch Road, Modular B Stanford, Stanford, CA, USA., Fang YH; Jiangxi Medical College, Shangrao, Jiangxi, China., Yu CF; Department of Orthopedic Surgery, Shangrao Municipal Hospital, Shangrao, Jiangxi, China., Zhao PP; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China., Qian Y; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China., Xia JW; Department of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China., Wei P; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China., Liu CR; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China., Yang MY; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China., Xu W; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China., Cheung CL; Department of Pharmacology and Pharmacy, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China., Xie SY; Binzhou Medical University, Yantai, Shandong, China. xieshuyang@bzmc.edu.cn., Zhou FS; Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. biozhoufs@163.com.; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui, China. biozhoufs@163.com., Rong XL; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. rongxiaoli123@gmail.com., Zheng HF; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. houf.zheng@suda.edu.cn.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China. houf.zheng@suda.edu.cn.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China. houf.zheng@suda.edu.cn.
Source: Nature communications [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 11711. Date of Electronic Publication: 2025 Nov 28.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Genetically informed causal links between gut microbiota and bone mass: pleiotropy and metabolic mediation.
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  Data: <searchLink fieldCode="AU" term="%22Guan+PL%22">Guan PL</searchLink>; College of Life Sciences, Zhejiang University, Hangzhou, China.; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Yuan+CD%22">Yuan CD</searchLink>; Department of Dermatology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P.R. China.<br /><searchLink fieldCode="AU" term="%22Han+MY%22">Han MY</searchLink>; Institute for immunity, Transplantation and Infection, Stanford Medicine, Stanford University, 1215 Welch Road, Modular B Stanford, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Fang+YH%22">Fang YH</searchLink>; Jiangxi Medical College, Shangrao, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Yu+CF%22">Yu CF</searchLink>; Department of Orthopedic Surgery, Shangrao Municipal Hospital, Shangrao, Jiangxi, China.<br /><searchLink fieldCode="AU" term="%22Zhao+PP%22">Zhao PP</searchLink>; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Qian+Y%22">Qian Y</searchLink>; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China.<br /><searchLink fieldCode="AU" term="%22Xia+JW%22">Xia JW</searchLink>; Department of Neurology, Xuanwu Hospital Capital Medical University, National Center for Neurological Disorders, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wei+P%22">Wei P</searchLink>; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Liu+CR%22">Liu CR</searchLink>; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Yang+MY%22">Yang MY</searchLink>; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink>; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Cheung+CL%22">Cheung CL</searchLink>; Department of Pharmacology and Pharmacy, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong, SAR, China.<br /><searchLink fieldCode="AU" term="%22Xie+SY%22">Xie SY</searchLink>; Binzhou Medical University, Yantai, Shandong, China. xieshuyang@bzmc.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+FS%22">Zhou FS</searchLink>; Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. biozhoufs@163.com.; Key Laboratory of Dermatology (Anhui Medical University), Ministry of Education, Hefei, Anhui, China. biozhoufs@163.com.<br /><searchLink fieldCode="AU" term="%22Rong+XL%22">Rong XL</searchLink>; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. rongxiaoli123@gmail.com.<br /><searchLink fieldCode="AU" term="%22Zheng+HF%22">Zheng HF</searchLink>; Suzhou Laboratory of Precision Health and Data Science, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. houf.zheng@suda.edu.cn.; Institute of Health Data Science, Soochow University, Suzhou, Jiangsu, China. houf.zheng@suda.edu.cn.; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study and Westlake University, Hangzhou, China. houf.zheng@suda.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2025 Nov 28; Vol. 16 (1), pp. 11711. <i>Date of Electronic Publication: </i>2025 Nov 28.
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