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Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries.

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Title: Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries.
Authors: O'Brien EM; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA., Tylek T; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA., Geisler HC; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA., Mukalel AJ; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA., Whitaker RC; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA., Sung S; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA., Binder-Markey BI; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA; Department of Physical Therapy and Rehabilitation Sciences, Drexel University, Philadelphia, PA, USA., Weissman D; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mitchell MJ; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA., Spiller KL; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA. Electronic address: kls35@drexel.edu.
Source: Biomaterials [Biomaterials] 2026 May; Vol. 328, pp. 123869. Date of Electronic Publication: 2025 Nov 25.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries.
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  Data: <searchLink fieldCode="AU" term="%22O'Brien+EM%22">O'Brien EM</searchLink>; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tylek+T%22">Tylek T</searchLink>; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Geisler+HC%22">Geisler HC</searchLink>; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mukalel+AJ%22">Mukalel AJ</searchLink>; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Whitaker+RC%22">Whitaker RC</searchLink>; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Sung+S%22">Sung S</searchLink>; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Binder-Markey+BI%22">Binder-Markey BI</searchLink>; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA; Department of Physical Therapy and Rehabilitation Sciences, Drexel University, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Weissman+D%22">Weissman D</searchLink>; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Mitchell+MJ%22">Mitchell MJ</searchLink>; Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Spiller+KL%22">Spiller KL</searchLink>; School of Biomedical Engineering, Science, and Health Systems, Drexel University, Philadelphia, PA, USA. Electronic address: kls35@drexel.edu.
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