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Randomized double-blind crossover trial of a transdermal maltose dissolvable microneedle patch for topical anesthesia before intravenous cannulation for thalassemia children.

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Title: Randomized double-blind crossover trial of a transdermal maltose dissolvable microneedle patch for topical anesthesia before intravenous cannulation for thalassemia children.
Authors: Jalal MIA; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia., Ooi KS; Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Pakar Kanak-Kanak, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia., Foo KC; Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Pakar Kanak-Kanak, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia., Hamzah AA; Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia. azlanhamzah@ukm.edu.my., Dee CF; Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia., Ooi PC; Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia., Buyong MR; Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia., Rahman ASA; Institute of Microengineering and Nanoelectronics, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia., Low TY; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia.; Sir Jeffrey Cheah Sunway Medical School, Faculty of Medical and Life Sciences, Sunway University, 47500, Bandar Sunway, Malaysia., Chua XY; Pharmacy Department, Hospital Canselor Tuanku Muhriz, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia., Lau DSC; Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Pakar Kanak-Kanak, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia., Cheah FC; Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia, Hospital Pakar Kanak-Kanak, Jalan Yaacob Latif, 56000, Kuala Lumpur, Malaysia. cheahfc@hctm.ukm.edu.my.; Placenta and Perinatal Research Group, Universiti Kebangsaan Malaysia, 43600, Bangi, Malaysia. cheahfc@hctm.ukm.edu.my.
Source: Scientific reports [Sci Rep] 2025 Nov 29; Vol. 16 (1), pp. 671. Date of Electronic Publication: 2025 Nov 29.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2045-2322
DOI:10.1038/s41598-025-30279-9