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Picornavirus VP2 protein suppresses innate immunity through selective autophagic degradation of IKBKE/IKKε.

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Title: Picornavirus VP2 protein suppresses innate immunity through selective autophagic degradation of IKBKE/IKKε.
Authors: Li K; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Zhang X; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Dong D; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Zhu B; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Wang S; School of Pharmacy, Lanzhou University, Lanzhou, China., Wen X; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Cao W; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Ru Y; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Tian H; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Zhu G; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China., He J; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Guo J; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China., Dai J; School of Pharmacy, Lanzhou University, Lanzhou, China., Zheng H; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China., Yang F; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China., Zhu Z; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Source: Autophagy [Autophagy] 2026 Feb; Vol. 22 (2), pp. 330-350. Date of Electronic Publication: 2025 Dec 14.
Publication Type: Journal Article
Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101265188 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8635 (Electronic) Linking ISSN: 15548627 NLM ISO Abbreviation: Autophagy Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Picornavirus VP2 protein suppresses innate immunity through selective autophagic degradation of IKBKE/IKKε.
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  Data: <searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Dong+D%22">Dong D</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; School of Pharmacy, Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Wen+X%22">Wen X</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Cao+W%22">Cao W</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Ru+Y%22">Ru Y</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Tian+H%22">Tian H</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+G%22">Zhu G</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22He+J%22">He J</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Guo+J%22">Guo J</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; WOAH/National Reference Laboratory for Foot-and-Mouth Disease, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Dai+J%22">Dai J</searchLink>; School of Pharmacy, Lanzhou University, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zheng+H%22">Zheng H</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Yang+F%22">Yang F</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Z%22">Zhu Z</searchLink>; State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
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  Data: <searchLink fieldCode="JN" term="%22101265188%22">Autophagy</searchLink> [Autophagy] 2026 Feb; Vol. 22 (2), pp. 330-350. <i>Date of Electronic Publication: </i>2025 Dec 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Taylor+%26+Francis%22">Taylor & Francis </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101265188 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1554-8635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215548627%22">15548627 </searchLink><i>NLM ISO Abbreviation: </i>Autophagy <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1080/15548627.2025.2597460
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      – Code: eng
        Text: English
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        StartPage: 330
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      – TitleFull: Picornavirus VP2 protein suppresses innate immunity through selective autophagic degradation of IKBKE/IKKε.
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              Text: 2026 Feb
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