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Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery.

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Title: Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery.
Authors: MacLeod AK; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Merino C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Viera-Morilla S; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain., Frame L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Tavendale A; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Duncan C; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Ferguson L; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Pinto EG; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Simeons FRC; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Gomez-Jimenez V; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain., García AB; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain., Riley J; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Shishikura Y; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K., Martínez-Martínez MS; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain., Wolf CR; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, U.K., Read KD; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
Source: ACS infectious diseases [ACS Infect Dis] 2025 Dec 12; Vol. 11 (12), pp. 3529-3541. Date of Electronic Publication: 2025 Nov 30.
Publication Type: Journal Article
Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE
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  Data: Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery.
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  Data: <searchLink fieldCode="AU" term="%22MacLeod+AK%22">MacLeod AK</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Merino+C%22">Merino C</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Viera-Morilla+S%22">Viera-Morilla S</searchLink>; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Frame+L%22">Frame L</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Tavendale+A%22">Tavendale A</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Duncan+C%22">Duncan C</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Ferguson+L%22">Ferguson L</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Pinto+EG%22">Pinto EG</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Simeons+FRC%22">Simeons FRC</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Gomez-Jimenez+V%22">Gomez-Jimenez V</searchLink>; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22García+AB%22">García AB</searchLink>; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Riley+J%22">Riley J</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Shishikura+Y%22">Shishikura Y</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.<br /><searchLink fieldCode="AU" term="%22Martínez-Martínez+MS%22">Martínez-Martínez MS</searchLink>; Global Health Medicines R&D, GSK, Tres Cantos, 28760 Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Wolf+CR%22">Wolf CR</searchLink>; Division of Systems Medicine, Jacqui Wood Cancer Centre, School of Medicine, University of Dundee, Ninewells Hospital, Dundee DD2 4GD, U.K.<br /><searchLink fieldCode="AU" term="%22Read+KD%22">Read KD</searchLink>; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
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